ArticleScandinavian journal of trauma, resuscitation and emergency medicine2021
Which injured patients with moderate fibrinogen deficit need fibrinogen supplementation?
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Viscoelastic haemostatic assays in chronic liver disease-Profiling coagulation in the emergency department.Vox sanguinis · 2026Article
- Fibrinogen supplementation enhances antivenom efficacy in treating coagulopathy due to hemotoxic snakebite envenoming byFrontiers in medicine · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundIn severely injured patients, fibrinogen supplementation is recommended when fibrinogenemia is < 1.5 g L
methodsProspective analysis of retrospectively collected data from a trauma registry (01/2011-12/2019). MFD-C was defined by a fibrinogenemia 1.51-1.99 g L
results1076 patients were included in the study and 266 (27%) had MFD-C, among them, 122/266 (46%) received fibrinogen. Patients with MFD-C who received fibrinogen were more severely injured (ISS: 27 [19-36] vs. 24 [17-29]) and had more impaired vital signs (base deficit: 5.4 [3.6-7.8] vs. 3.8 [2.0-6.0]). Linear regression analysis found a positive correlation between fibrinogen level and FIBTEM-A5 (r: 0.805). For a fibrinogen level < 1.5 g L
conclusionsWe have shown in this study an association between shock parameters and fibrinogen administration. Further studies are needed to determine how these parameters may be used to guide fibrinogen administration in trauma patients with MFD.
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