ArticleJournal of translational medicine2021
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study.
Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Whole-brain radiotherapy with simultaneous integrated boost in treatment of patients with brain metastases: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Periodontal Disease Elevates IL-6 Levels During Initial Symptoms of COVID-19.Diagnostics (Basel, Switzerland) · 2025Article
- Relationship Between Periodontitis and the Severity of Lung Infection Caused by COVID-19: A Case-Control Observational Study.Health science reports · 2025Article
- Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.World journal of virology · 2024Review
- The role of viruses in oral mucosal lesions.Periodontology 2000 · 2024Review
- Associations between 25 hydroxyvitamin D concentration and spontaneous abortion.BMC public health · 2024Article
- A prospective study on maternal periodontal diseases and neonatal adverse outcomes.Acta odontologica Scandinavica · 2024Article
- Is There a Correlation Between Periodontal Disease Symptoms and the COVID-19 Vaccination?Cureus · 2024Article
- Periodontal and Peri-Implant Diagnosis: Current Evidence and Future Directions.Diagnostics (Basel, Switzerland) · 2024Article
- Unmasking the Silent Threat: Periodontal Health's Impact on COPD Severity and Hospitalization.Journal of personalized medicine · 2023Article
- Association between periodontal disease and chronic obstructive pulmonary disease.The Japanese dental science review · 2023Review
- Relationship between the Social Development Index and Self-Reported Periodontal Conditions.Healthcare (Basel, Switzerland) · 2023Article
- Unvaccinated periodontal patients with a history of COVID-19: clinical findings in a Dental School setting.Brazilian dental journal · 2023Article
- Association between periodontitis and COVID-19 infection: a two-sample Mendelian randomization study.PeerJ · 2023Article
- Epidemiological pattern of COVID-19 and its association with periodontal health in an urban Indian cohort.Frontiers in public health · 2023Article
- Associations between Periodontitis, COVID-19, and Cardiometabolic Complications: Molecular Mechanisms and Clinical Evidence.Metabolites · 2022Review
- A Multimodal Deep Learning Approach to Predicting Systemic Diseases from Oral Conditions.Diagnostics (Basel, Switzerland) · 2022Article
- Covid-19 and SARS-CoV-2 infection in periodontology: A narrative review.Journal of periodontal research · 2022Review
- Diagnostic performance of the AAP/EFP classification and the CDC/AAP case definition among pregnant women and a practical screening tool for maternal periodontal diseases.Journal of periodontal research · 2022Article
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11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEmerging evidence shows that periodontal disease (PD) may increase the risk of Coronavirus disease 2019 (COVID-19) complications. Here, we undertook a two-sample Mendelian randomization (MR) study, and investigated for the first time the possible causal impact of PD on host susceptibility to COVID-19 and its severity.
methodsSummary statistics of COVID-19 susceptibility and severity were retrieved from the COVID-19 Host Genetics Initiative and used as outcomes. Single nucleotide polymorphisms associated with PD in Genome-wide association study were included as exposure. Inverse-variance weighted (IVW) method was employed as the main approach to analyze the causal relationships between PD and COVID-19. Three additional methods were adopted, allowing the existence of horizontal pleiotropy, including MR-Egger regression, weighted median and weighted mode methods. Comprehensive sensitivity analyses were also conducted for estimating the robustness of the identified associations.
resultsThe MR estimates showed that PD was significantly associated with significantly higher susceptibility to COVID-19 using IVW (OR = 1.024, P = 0.017, 95% CI 1.004-1.045) and weighted median method (OR = 1.029, P = 0.024, 95% CI 1.003-1.055). Furthermore, it revealed that PD was significantly linked to COVID-19 severity based on the comparison of hospitalization versus population controls (IVW, OR = 1.025, P = 0.039, 95% CI 1.001-1.049; weighted median, OR = 1.030, P = 0.027, 95% CI 1.003-1.058). No such association was observed in the cohort of highly severe cases confirmed versus those not hospitalized due to COVID-19.
conclusionsWe provide evidence on the possible causality of PD accounting for the susceptibility and severity of COVID-19, highlighting the importance of oral/periodontal healthcare for general wellbeing during the pandemic and beyond.
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