Evidence map›Paper›PMID 34952487›Full record

ArticleClinical imaging2022

Persistent inter-observer variability of breast density assessment using BI-RADS® 5th edition guidelines.

Leah H Portnow, Dianne Georgian-Smith, Irfanullah Haider, Mirelys Barrios, Camden P Bay, Kerrie P Nelson, Sughra Raza

Open access · greenAbstract read
In one paragraph

Article in Clinical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

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  10. Local Diagnostic Reference Levels in Digital Breast Tomosynthesis.Journal of medical radiation sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leah H PortnowBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America. Electronic address: lportnow@bwh.harvard.edu.
Dianne Georgian-SmithBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America.
Irfanullah HaiderBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America.
Mirelys BarriosBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America.
Camden P BayBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America.
Kerrie P NelsonBoston University, Department of Biostatistics, 801 Massachusetts Avenue 3rd Floor, Boston, MA 02118, United States of America.
Sughra RazaBrigham and Women's Hospital, Department of Radiology, 75 Francis Street, Boston, MA 02115, United States of America.
Brigham and Women's Hospital · USBoston University · US

Funding

Improving Accuracy and Reliability in Cancer Screening TestsR01CA226805 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, KERRIE P · 2018 to 2021
$1.2M
Model Agreement in Cancer Diagnostic TestsR01CA172463 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, KERRIE P · 2014 to 2017
$995k
NCI NIH HHS R01 CA172463NCI NIH HHS R01 CA226805
6 · The paper itself

Abstract

objectivesDue to most states' legislation, mammographic density categorization has potentially far-reaching implications, but remains subjective based on BIRADS® guidelines. We aimed to determine 1) effect of BI-RADS® 5th edition (5th-ed) vs 4th-edition (4th-ed) guidelines on reader agreement regarding density assessment; 2) 5th-ed vs 4th-ed density distribution, and visual vs quantitative assessment agreement; 3) agreement between experienced vs less experienced readers.

methodsIn a retrospective review, six breast imaging radiologists (BIR) (23-30 years' experience) visually assessed density of 200 screening mammograms performed September 2012-January 2013 using 5th-ed guidelines. Results were compared to 2016 data of the same readers evaluating the same mammograms using 4th-ed guidelines after a training module. 5th-ed density categorization by seven junior BIR (1-5 years' experience) was compared to eight experienced BIR. Nelson et al.'s kappas (κ

resultsInter-reader weighted agreement using 5th-ed is moderately strong, 0.73 (κ

conclusionThere is persistent subjectivity of visually assessed mammographic density using 5th-ed guidelines; experience does not correlate with better inter-reader agreement.

Indexed as

Breast DensityBreast NeoplasmsFemaleHumansMammographyObserver VariationRadiologistsAlgorithmsBreast densityComputing methodologiesMammography

Identifiers

PMID34952487
PMCPMC8857050
OpenAlexW4200117696

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.