Evidence map›Paper›PMID 34952463›Full record

ArticleRedox biology2022

[

Kiran Kumar Solingapuram Sai, Xiaofei Chen, Zhe Li, Caigang Zhu, Kirtikar Shukla, Tom E Forshaw, Hanzhi Wu, Stephen A Vance, Buddhika Liyana Pathirannahel, Megan Madonna and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Profiling the landscape of cysteine posttranslational modifications in brain aging and neurodegeneration.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  2. Review
  3. [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Xiaofei ChenDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Zhe LiDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA.
Caigang ZhuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Kirtikar ShuklaDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Tom E ForshawDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Hanzhi WuDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Stephen A VanceDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA.
Buddhika Liyana PathirannahelDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Megan MadonnaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Mark W DewhirstDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Allen W TsangDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Leslie B PooleDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Nimmi RamanujamDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
S Bruce KingDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: cfurdui@wakehealth.edu.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction PathwaysR35GM135179 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 2020 to 2024
$1.9M
A Quantitative Optical Sensor to Monitor Tumor Vascular PhysiologyR42CA156901 · NCI · ZENALUX BIOMEDICAL, INC. · PI VON WINDHEIM, JESKO · 2014 to 2015
$1.3M
NCI NIH HHS P30 CA012197NCI NIH HHS R42 CA156901NIGMS NIH HHS R35 GM135179
6 · The paper itself

Abstract

Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [

Indexed as

Fluorodeoxyglucose F18Head and Neck NeoplasmsAnimalsHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyTissue DistributionFluorodeoxyglucose F18[18F]F-DCPHead and Neck Squamous Cell CancerPET imagingProtein sulfenylationRadiation resistance

Identifiers

PMID34952463
PMCPMC8715125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.