Evidence map›Paper›PMID 34952139›Full record

ArticleExperimental hematology2022

Anti-CD20 monoclonal antibodies inhibit seropositive response to Covid-19 vaccination in non-Hodgkin lymphoma patients within 6 months after treatment.

Ariella Tvito, Aaron Ronson, Renan Ghosheh, Mira Kharit, Jakob Ashkenazi, Sophie Magen, Ellen Broide, Emmanuel Benayoun, Jacob M Rowe, Yishai Ofran and 1 more

Open access · greenAbstract read
In one paragraph

Article in Experimental hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ariella TvitoDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel. Electronic address: ariellat@szmc.org.il.
Aaron RonsonDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Renan GhoshehDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Mira KharitDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Jakob AshkenaziDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Sophie MagenImmunology Laboratories, Shaare Zedek Medical Center, Jerusalem, Israel.
Ellen BroideImmunology Laboratories, Shaare Zedek Medical Center, Jerusalem, Israel.
Emmanuel BenayounImmunology Laboratories, Shaare Zedek Medical Center, Jerusalem, Israel.
Jacob M RoweDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Yishai OfranDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Chezi GanzelDepartment of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Shaare Zedek Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Covid-19 pandemic has caused millions of deaths worldwide. Although vaccines have been developed, patients on immunosuppressive therapy are less likely to respond. This study was aimed at investigating the efficacy of a Covid-19 vaccine (Pfizer-BioNTech) in patients with non-Hodgkin lymphoma treated with anti-CD20 monoclonal antibodies. Only 1 of 28 lymphoma patients (3.6%) developed a seropositive response, compared with 100% (28/28) of the healthy volunteers. The low levels of CD19

Indexed as

COVID-19Lymphoma, Non-HodgkinAntibodies, MonoclonalCOVID-19 VaccinesHumansPandemicsSARS-CoV-2VaccinationAntibodies, MonoclonalCOVID-19 Vaccines

Identifiers

PMID34952139
PMCPMC8691955
OpenAlexW4200194281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.