ArticleAnnals of intensive care2021
Patterns of ICU admissions and outcomes in patients with solid malignancies over the revolution of cancer treatment.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- External validity limitations of randomized trials cited in adult critical care clinical practice guidelines: a systematic review of guidelines published from 2015 to 2020.Frontiers in medicine · 2026Pooled it
- Incremental Prognostic Value of Albumin-Anchored Inflammatory Ratios Beyond a SOFA-Based Model in a Medical ICU: A Retrospective Cohort Study.Metabolites · 2026Article
- Patterns of Care in the Final Week of Life: A Comparative Analysis of Aggressive Treatment Versus Comfort-Centered Care Across Healthcare Settings.Medicina (Kaunas, Lithuania) · 2026Article
- Improving mortality prediction in critically ill cancer patients with a multidimensional machine learning model.Intensive care medicine experimental · 2026Article
- Association between palliative care consultation and care transition outcomes among hospitalized advanced cancer patients.JNCI cancer spectrum · 2026Article
- Oncologic and physiologic predictors of mortality after intensive care unit admission in patients with lung cancer.Annals of the American Thoracic Society · 2026Article
- [Clinical characteristics of pediatric patients with acute lymphoblastic leukemia admitted to the pediatric intensive care unit].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Factors associated with functional independence at hospital discharge and 6 months post-hospitalization in intensive care unit survivors with cancer: A prospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Breaking Barriers for Intensive Care Admission in Patients With Advanced HCC on Immunotherapy.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Acute neurological dysfunction in critically ill patients with solid tumors: A 14-year retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Prediction of 90-day mortality among cancer patients with unplanned hospitalisation: a retrospective validation study of three prognostic scores.The Lancet regional health. Europe · 2025Article
- Explainable machine learning model for prediction of 28-day all-cause mortality in immunocompromised patients in the intensive care unit: a retrospective cohort study based on MIMIC-IV database.European journal of medical research · 2025Article
- Clinical impact and safety of continuous renal replacement therapy in critically ill patients with solid tumors and acute kidney injury: a retrospective cohort analysis.American journal of cancer research · 2025Article
- Physical and Cognitive Impairments at ICU Discharge are Associated with High Long-Term Mortality in ICU Survivors with Solid Malignancies: A Retrospective Cohort Study.Therapeutics and clinical risk management · 2025Article
- Characteristics Associated with Length of Stay in Intensive Care Unit for Cancer Patients in China: A Nationwide Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2025Article
- Trends in use of intensive care during hospitalizations at the end-of-life among older adults with advanced cancer.Journal of the American Geriatrics Society · 2024Article
- Short-term and long-term outcomes of critically ill patients with solid malignancy: a retrospective cohort study.The Korean journal of internal medicine · 2024Article
- Outcome of patients with solid malignancies considered for intensive care unit admission: a single-center prospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Factors associated with cancer treatment resumption after ICU stay in patients with solid tumors.Annals of intensive care · 2024Article
- Decreased Long-Term Survival of Patients With Newly Diagnosed Cancer Discharged Home After Unplanned ICU Admission: A Prospective Observational Study.Critical care explorations · 2024Observational
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor therapeutic advances including immunotherapy and targeted therapies have been changing the face of oncology and resulted in improved prognosis as well as in new toxic complications. The aim of this study is to appraise the trends in intensive care unit (ICU) admissions and outcomes of critically ill patients with solid malignancies. We performed a retrospective single-centre study over a 12-year period (2007-2018) including adult patients with solid malignancies requiring unplanned ICU admission. Admission patterns were classified as: (i) specific if directly related to the underlying cancer; (ii) non-specific; (iii) drug-related or procedural adverse events.
results1525 patients were analysed. Lung and gastro-intestinal tract accounted for the two main tumour sites. The proportion of patients with metastatic diseases increased from 48.6% in 2007-2008 to 60.2% in 2017-2018 (p = 0.004). Critical conditions were increasingly related to drug- or procedure-related adverse events, from 8.8% of ICU admissions in 2007-2008 to 16% in 2017-2018 (p = 0.01). The crude severity of critical illness at ICU admission did not change over time. The ICU survival rate was 77.4%, without any significant changes over the study period. Among the 1279 patients with complete follow-up, the 1-year survival rate was 33.2%. Independent determinants of ICU mortality were metastatic disease, cancer in progression under treatment, admission for specific complications and the extent of organ failures (invasive and non-invasive ventilation, inotropes/vasopressors, renal replacement therapy and SOFA score). One-year mortality in ICU-survivors was independently associated with lung cancer, metastatic disease, cancer in progression under treatment, admission for specific complications and decision to forgo life-sustaining therapies.
conclusionAdvances in the management and the prognosis of solid malignancies substantially modified the ICU admission patterns of cancer patients. Despite underlying advanced and often metastatic malignancies, encouraging short-term and long-term outcomes should help changing the dismal perception of critically ill cancer patients.
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