Evidence map›Paper›PMID 34951656›Full record

SynthesisDiabetologia2022

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Carolina G Downie, Sofia F Dimos, Stephanie A Bien, Yao Hu, Burcu F Darst, Linda M Polfus, Yujie Wang, Genevieve L Wojcik, Ran Tao, Laura M Raffield and 21 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. The Multiethnic Cohort: A Resource for the Study of Genetic and Nongenetic Cancer Risk across Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 15 institutions in 1 country.

Carolina G DownieDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cdownie@live.unc.edu.ORCID 0000-0001-6972-9981
Sofia F DimosDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-0315-9434
Stephanie A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-8713-4583
Yao HuDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-2810-646X
Burcu F DarstDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-6205-4632
Linda M PolfusDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1123-2117
Yujie WangDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-1087-2182
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-7206-8088
Ran TaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1106-2923
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Nicole D ArmstrongDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-6483-4560
Hannah G PolikowskyDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-7226-9752
Jennifer E BelowDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-6372-6402
Adolfo CorreaDepartment of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-9501-600X
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1442-2023
Laura J F Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-0820-7300
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0003-0561-3538
Lawrence S PhillipsAtlanta VA Medical Center, Decatur, GA, USA.ORCID 0000-0002-6542-8046
Simin LiuDepartment of Medicine, Division of Endocrinology, Warren Alpert School of Medicine, Brown University, Providence, RI, USA.ORCID 0000-0003-2098-3844
James S PankowDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.ORCID 0000-0001-7076-483X
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Jerome I RotterDepartment of Pediatrics, Genome Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-7191-1723
Steven BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0001-8539-5416
Tara C MatiseDepartment of Genetics, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-7147-492X
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8903-0366
Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-1044-8162
Christopher A HaimanDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-0097-9971
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8532-5087
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6380-1735
Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-3583-8239
University of North Carolina at Chapel Hill · USFred Hutch Cancer Center · USUniversity of Southern California · USVanderbilt University Medical Center · USRutgers, The State University of New Jersey · USUniversity of Alabama at Birmingham · USBrown University · USEmory University · USIcahn School of Medicine at Mount Sinai · USJackson Memorial Hospital · USJohns Hopkins University · USNorthwestern University · USUCLA Medical Center · USUniversity of Minnesota · USUniversity of Virginia · US

Funding

Glycemia Reduction Approaches in Diabetes: A comparative effectiveness studyU01DK098246 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI KRAUSE-STEINRAUF, HEIDI, LACHIN, JOHN M · 2012 to 2022
$238.9M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
TASK ORDER NO. 4, STSS PROGRAM SUPPORT AND TRANSITION-IN (4)75N95021D00001 · NIDA · AXLE INFORMATICS, LLC · PI MAYS, GARY · 2021 to 2022
$27.9M
BLRD VA I01 BX005831CLC NIH HHS 75N90020D00002CLC NIH HHS 75N90020D00003CLC NIH HHS 75N90021D00002CLC NIH HHS 75N90021D00004CSRD VA I01 CX001737FIC NIH HHS D43 TW009077NCATS NIH HHS KL2 TR002490NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR002378NCATS NIH HHS UL1 TR003098NCI NIH HHS 75N91021D00001NCI NIH HHS P01 CA033619NCI NIH HHS R01 CA054281NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA136792NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268201300003CNHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01 HG004790NHGRI NIH HHS U01 HG004802NHGRI NIH HHS U01 HG004803NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007419NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00007NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201300001CNHLBI NIH HHS HHSN268201300003INHLBI NIH HHS HHSN268201300004CNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL108427NHLBI NIH HHS R01 HL123782NHLBI NIH HHS R01 HL136666NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL142825NHLBI NIH HHS R01 HL147853NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R35 HL155466NHLBI NIH HHS T32 HL007055NHLBI NIH HHS T32 HL129982NIAID NIH HHS 75N93020D00002NIAID NIH HHS R03 AI133172NIAID NIH HHS R21 AI156161NIA NIH HHS R01 AG065357NICHD NIH HHS 75N94020D00003NICHD NIH HHS 75N94020D00007NICHD NIH HHS 75N94021D00001NICHD NIH HHS 75N94021D00002NICHD NIH HHS R01 HD030880NIDA NIH HHS 75N95020D00002NIDA NIH HHS 75N95020D00003NIDA NIH HHS 75N95020D00004NIDA NIH HHS 75N95020D00005NIDA NIH HHS 75N95020D00007NIDA NIH HHS 75N95021D00001NIDDK NIH HHS P30 DK020541NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK104371NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK124097NIDDK NIH HHS R18 DK066204NIDDK NIH HHS R21 DK099716NIDDK NIH HHS U01 DK098246NIDDK NIH HHS U34 DK091958NIEHS NIH HHS 75N96020D00002NIEHS NIH HHS 75N96020D00003NIH HHS 75N98020D00007NIH HHS 75N98021D00002NIH HHS 75N98021D00004NIH HHS 75N98021D00005NIH HHS S10 OD028685NIMHD NIH HHS HHSN268201800013INIMHD NIH HHS P20 MD000170NINDS NIH HHS U01 NS041588NLM NIH HHS 75N97021D00003ORFDO NIH HHS 75N99020D00002ORFDO NIH HHS 75N99020D00003ORFDO NIH HHS 75N99020D00004ORFDO NIH HHS 75N99020D00005ORFDO NIH HHS 75N99020D00006ORFDO NIH HHS 75N99020D00007ORFDO NIH HHS 75N99021D00001ORFDO NIH HHS 75N99021D00002WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

aims/hypothesisType 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA

methodsWe conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbA

resultsFour novel associations were identified (p < 5 × 10 CONCLUSIONS/

interpretationOur findings provide new insights into the genetic architecture of glycaemic traits and highlight the continued importance of conducting genetic studies in diverse populations. DATA AVAILABILITY: Full summary statistics from each of the population-specific and transethnic results are available at NHGRI-EBI GWAS catalog ( https://www.ebi.ac.uk/gwas/downloads/summary-statistics ).

Indexed as

Diabetes Mellitus, Type 2Genome-Wide Association StudyBlood GlucoseGenomicsHumansPolymorphism, Single NucleotideBlood GlucoseFine-mappingGenome-wide association studyGlucoseGlycaemic traitsHbA1cInsulinTransethnic population

Identifiers

PMID34951656
PMCPMC8810722
OpenAlexW4200139297

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.