ArticlePlant physiology2022
Antagonistic modules regulate photosynthesis-associated nuclear genes via GOLDEN2-LIKE transcription factors.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 40 citations in OpenAlex.
- Arabidopsis GOLDEN2-LIKE transcription factors interact with ABA-INSENSITIVE 4 to modulate cotyledon greening in light-exposed etiolated seedlings.Journal of experimental botany · 2026Article
- SIB1-SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana.Journal of integrative plant biology · 2026Article
- Biogenic retrograde signaling via GUN1 ensures thermotolerant chloroplast biogenesis during seedling establishment in Arabidopsis thaliana.Journal of integrative plant biology · 2026Article
- Singlet Oxygen Generation and Signaling in Higher Plants.International journal of molecular sciences · 2026Review
- Salicylic acid and ROS signaling modulate hypocotyl elongation in darkness via NPR1 and EX1.Science advances · 2025Article
- Redox regulation of LSD1/CATALASE 2 phase separation condensates controls location and functions.The New phytologist · 2025Article
- SunflowerBiology · 2025Article
- Comparative analysis of synteny and functional divergence of APX genes in Fragaria vesca and Fragaria×ananassa.BMC plant biology · 2025Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2025Article
- ACT2.6: Global Gene Coexpression Network inGenes · 2025Article
- Genome-wide identification of the GLK transcription factor family in melon and its expression analysis under biotic and abiotic stresses.Frontiers in plant science · 2025Article
- EXECUTER1 and singlet oxygen signaling: A reassessment of nuclear activity.The Plant cell · 2024Article
- Overexpression ofInternational journal of molecular sciences · 2024Article
- The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis.The Plant cell · 2024Article
- BPG4 regulates chloroplast development and homeostasis by suppressing GLK transcription factors and involving light and brassinosteroid signaling.Nature communications · 2024Article
- The pleiotropic functions of GOLDEN2-LIKE transcription factors in plants.Frontiers in plant science · 2024Review
- A point mutation in the zinc-finger transcription factorFrontiers in plant science · 2024Article
- Chloroplasts prevent precocious flowering through a GOLDEN2-LIKE-B-BOX DOMAIN PROTEIN module.Plant communications · 2023Article
- Shade represses photosynthetic genes by disrupting the DNA binding of GOLDEN2-LIKE1.Plant physiology · 2023Article
- Coordinated regulation of the mitochondrial retrograde response by circadian clock regulators and ANAC017.Plant communications · 2023Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
GOLDEN2-LIKE (GLK) transcription factors drive the expression of photosynthesis-associated nuclear genes (PhANGs) indispensable for chloroplast biogenesis. Salicylic acid (SA)-induced SIGMA FACTOR-BINDING PROTEIN 1 (SIB1), a transcription coregulator and positive regulator of cell death, interacts with GLK1 and GLK2 to reinforce the expression of PhANGs, leading to photoinhibition of photosystem II and singlet oxygen (1O2) burst in chloroplasts. 1O2 then contributes to SA-induced cell death via EXECUTER 1 (EX1; 1O2 sensor protein)-mediated retrograde signaling upon reaching a critical level. This earlier finding has initiated research on the potential role of GLK1/2 and EX1 in SA signaling. Consistent with this view, we reveal that LESION-SIMULATING DISEASE 1 (LSD1), a transcription coregulator and negative regulator of SA-primed cell death, interacts with GLK1/2 to repress their activities in Arabidopsis (Arabidopsis thaliana). Overexpression of LSD1 repressed GLK target genes, including PhANGs, whereas loss of LSD1 enhanced their expression. Remarkably, LSD1 overexpression inhibited chloroplast biogenesis, resembling the characteristic glk1glk2 double mutant phenotype. Subsequent chromatin immunoprecipitation coupled with expression analyses further revealed that LSD1 inhibits the DNA-binding activity of GLK1 toward its target promoters. SA-induced nuclear-targeted SIB1 proteins appeared to interrupt the LSD1-GLK interaction, and the subsequent SIB1-GLK interaction activated EX1-mediated 1O2 signaling, elucidating antagonistic modules SIB1 and LSD1 in the regulation of GLK activity. Taken together, we provide a working model that SIB1 and LSD1, mutually exclusive SA-signaling components, antagonistically regulate GLK1/2 to fine-tune the expression of PhANGs, thereby modulating 1O2 homeostasis and related stress responses.
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