Evidence map›Paper›PMID 34951528›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022

An updated estimate of posttransplant survival after implementation of the new donor heart allocation policy.

Kevin A Lazenby, Nikhil Narang, Kenley M Pelzer, Gege Ran, William F Parker

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Low rates of inotropic support and durable left ventricular assist device placement among status 2 heart transplant candidates with temporary mechanical circulatory support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  4. Article
  5. Modernizing the national transplant database.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Review
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Post-transplant survival after normothermic regional perfusion versus direct procurement and perfusion in donation after circulatory determination of death in heart transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Observational
  12. Article
  13. Best practices for statistical analysis of pretransplant medical urgency.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  14. Article
  15. Clinical trends, risk factors, and temporal effects of post-transplant dialysis on outcomes following orthotopic heart transplantation in the 2018 United States heart allocation system.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023
    Article
  16. Article
  17. Review
  18. UNOS policy change benefits high-priority patients without harming those at low priority.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  19. Relationships between 2018 UNOS heart policy and transplant outcomes in metropolitan, micropolitan, and rural settings.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kevin A LazenbyPritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-5520-2855
Nikhil NarangDepartment of Medicine, University of Illinois-Chicago, Chicago, Illinois, USA.ORCID 0000-0002-9212-7070
Kenley M PelzerDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-8984-758X
Gege RanPritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-0815-7171
William F ParkerDepartment of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-6000-3153

Funding

Mending a Broken Heart Allocation System with Machine LearningK08HL150291 · NHLBI · UNIVERSITY OF CHICAGO · PI PARKER, WILLIAM F · 2020 to 2024
$713k
NHLBI NIH HHS K08 HL150291
6 · The paper itself

Abstract

The Organ Procurement and Transplant Network (OPTN) implemented a new heart allocation policy on October 18, 2018. Published estimates of lower posttransplant survival under the new policy in cohorts with limited follow-up may be biased by informative censoring. Using the Scientific Registry of Transplant Recipients, we used the Kaplan-Meier method to estimate 1-year posttransplant survival for pre-policy (November 1, 2016, to October 31, 2017) and post-policy cohorts (November 1, 2018, to October 31, 2019) with follow-up through March 2, 2021. We adjusted for changes in recipient population over time with a multivariable Cox proportional hazards model. To demonstrate the effect of inadequate follow-up on post-policy survival estimates, we repeated the analysis but only included follow-up through October 31, 2019. Transplant programs transplanted 2594 patients in the pre-policy cohort and 2761 patients in the post-policy cohort. With follow-up through March 2, 2021, unadjusted 1-year posttransplant survival was 90.6% (89.5%-91.8%) in the pre-policy cohort and 90.8% (89.7%-91.9%) in the post-policy cohort (adjusted HR = 0.93 [0.77-1.12]). Ignoring follow-up after October 31, 2019, the post-policy estimate was biased downward (1-year: 82.2%). When estimated with adequate follow-up, 1-year posttransplant survival under the new heart allocation policy was not significantly different.

Indexed as

Heart TransplantationTissue and Organ ProcurementHumansPolicyRegistriesTissue DonorsTransplant Recipientshealth services and outcomes researchheart transplantation/cardiologyOrgan Procurement and Transplantation Network (OPTN)patient survivalregistry/registry analysisScientific Registry for Transplant Recipients (SRTR)statistics

Identifiers

PMID34951528
PMCPMC9177535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.