Evidence map›Paper›PMID 34951427›Full record

ArticleNanoscale2022

Nanoengineered myogenic scaffolds for skeletal muscle tissue engineering.

Jacob P Quint, Mohamadmahdi Samandari, Laleh Abbasi, Evelyn Mollocana, Chiara Rinoldi, Azadeh Mostafavi, Ali Tamayol

Open access · bronzeAbstract read
In one paragraph

Article in Nanoscale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
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  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cleanroom-Free Fabrication of Microneedles for Multimodal Drug Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Porous biomaterial scaffolds for skeletal muscle tissue engineering.Frontiers in bioengineering and biotechnology · 2023
    Review
  20. Functional hydrogels for the repair and regeneration of tissue defects.Frontiers in bioengineering and biotechnology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jacob P QuintDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT 06030, USA. atamayol@uchc.edu.
Mohamadmahdi SamandariDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT 06030, USA. atamayol@uchc.edu.
Laleh AbbasiDepartment of Molecular, Cellular & Biomedical Sciences, The City College of New York, New York, NY, 10031, USA.ORCID http://orcid.org/0000-0001-7883-2112
Evelyn MollocanaDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Lincoln, NE, 68588, USA.ORCID http://orcid.org/0000-0002-0614-5484
Chiara RinoldiDepartment of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw 02-106, Poland.
Azadeh MostafaviDepartment of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Lincoln, NE, 68588, USA.
Ali TamayolDepartment of Biomedical Engineering, University of Connecticut, Farmington, CT 06030, USA. atamayol@uchc.edu.ORCID http://orcid.org/0000-0003-1801-2889
University of Nebraska–Lincoln · USUniversity of Connecticut · USCity College of New York · USInstitute of Fundamental Technological Research · PL

Funding

Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle lossR01AR077132 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHIN, SU RYON, TAMAYOL, ALI · 2021 to 2025
$2.6M
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle lossR01AR073822 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI TAMAYOL, ALI · 2018 to 2022
$1.8M
Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training ProgramT32AR079114 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2021 to 2025
$1.1M
NIAMS NIH HHS R01 AR073822NIAMS NIH HHS R01 AR077132NIAMS NIH HHS T32 AR079114
6 · The paper itself

Abstract

Extreme loss of skeletal muscle overwhelms the natural regenerative capability of the body, results in permanent disability and substantial economic burden. Current surgical techniques result in poor healing, secondary injury to the autograft donor site, and incomplete recuperation of muscle function. Most current tissue engineering and regenerative strategies fail to create an adequate mechanical and biological environment that enables cell infiltration, proliferation, and myogenic differentiation. In this study, we present a nanoengineered skeletal muscle scaffold based on functionalized gelatin methacrylate (GelMA) hydrogel, optimized for muscle progenitors' proliferation and differentiation. The scaffold was capable of controlling the release of insulin-like growth factor 1 (IGF-1), an important myogenic growth factor, by utilizing the electrostatic interactions with LAPONITE

Indexed as

Muscle DevelopmentTissue EngineeringGelatinHydrogelsMuscle, SkeletalGelatinHydrogels

Identifiers

PMID34951427
PMCPMC8900679
OpenAlexW4200167740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.