Evidence map›Paper›PMID 34951405›Full record

ArticleeLife2021

A dual endosymbiosis supports nutritional adaptation to hematophagy in the invasive tick

Marie Buysse, Anna Maria Floriano, Yuval Gottlieb, Tiago Nardi, Francesco Comandatore, Emanuela Olivieri, Alessia Giannetto, Ana M Palomar, Benjamin L Makepeace, Chiara Bazzocchi and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Transboundary and emerging diseases · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Co-occurrence ofOpen veterinary journal · 2026
    Article
  7. Article
  8. Article
  9. bioRxiv : the preprint server for biology · 2025
    Article
  10. Deep sequencing of 16mSystems · 2025
    Article
  11. Article
  12. Evolutionary Convergence of Nutritional Symbionts in Ticks.Environmental microbiology reports · 2025
    Article
  13. Genetic and genomic variability ofISME communications · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 7 countries.

Marie Buysse *MIVEGEC (Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle), Univ. Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Institut pour la Recherche et le Développement (IRD), Montpellier, France.ORCID 0000-0002-8160-2470
Anna Maria Floriano *Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Yuval GottliebKoret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Tiago NardiDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.ORCID 0000-0002-1248-9873
Francesco ComandatoreDepartment of Biomedical and Clinical Sciences L. Sacco and Pediatric Clinical Research Center, University of Milan, Milan, Italy.
Emanuela OlivieriDepartment of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Alessia GiannettoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Ana M PalomarCenter of Rickettsiosis and Arthropod-Borne Diseases (CRETAV), San Pedro University Hospital- Center of Biomedical Research from La Rioja (CIBIR), Logroño, Spain.ORCID 0000-0002-5461-5874
Benjamin L MakepeaceInstitute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Chiara BazzocchiDepartment of Veterinary Medicine, University of Milan, Lodi, Italy.
Alessandra CafisoDepartment of Veterinary Medicine, University of Milan, Lodi, Italy.
Davide Sassera *Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Olivier Duron *MIVEGEC (Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle), Univ. Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Institut pour la Recherche et le Développement (IRD), Montpellier, France.
University of Milan · ITUniversity of Pavia · ITCentre National de la Recherche Scientifique · FRHebrew University of Jerusalem · ILHospital San Pedro · ESSewanee: The University of the South · USUniversity of Liverpool · GBUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many animals are dependent on microbial partners that provide essential nutrients lacking from their diet. Ticks, whose diet consists exclusively on vertebrate blood, rely on maternally inherited bacterial symbionts to supply B vitamins. While previously studied tick species consistently harbor a single lineage of those nutritional symbionts, we evidence here that the invasive tick

Indexed as

AnimalsFrancisellaGene Transfer, HorizontalIxodidaeRickettsialesSymbiosisVitamin B ComplexVitamin B Complexendosymbiosisevolutionary biologyFrancisellahematophagyHyalommaMidichloria

Identifiers

PMID34951405
PMCPMC8709577
OpenAlexW4200078781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.