Evidence map›Paper›PMID 34951084›Full record

ArticleHuman brain mapping2022

Elucidating the structural-functional connectome of language in glioma-induced aphasia using nTMS and DTI.

Haosu Zhang, Sebastian Ille, Lisa Sogerer, Maximilian Schwendner, Axel Schröder, Bernhard Meyer, Benedikt Wiestler, Sandro M Krieg

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Haosu ZhangDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0000-0002-5069-1095
Sebastian IlleDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Lisa SogererDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Maximilian SchwendnerDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Axel SchröderDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Bernhard MeyerDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0000-0001-6486-7955
Benedikt WiestlerSchool of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0002-2963-7772
Sandro M KriegDepartment of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.ORCID 0000-0003-4050-1531
TUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma-induced aphasia (GIA) is frequently observed in patients with newly diagnosed gliomas. Previous studies showed an impact of gliomas not only on local brain regions but also on the functionality and structure of brain networks. The current study used navigated transcranial magnetic stimulation (nTMS) to localize language-related regions and to explore language function at the network level in combination with connectome analysis. Thirty glioma patients without aphasia (NA) and 30 patients with GIA were prospectively enrolled. Tumors were located in the vicinity of arcuate fasciculus-related cortical and subcortical regions. The visualized ratio (VR) of each tract was calculated based on their respective fractional anisotropy (FA) and maximal FA. Using a thresholding method of each tract at 25% VR and 50% VR, DTI-based tractography was performed to construct structural brain networks for graph-based connectome analysis, containing functional data acquired by nTMS. The average degree of left hemispheric networks (M

Indexed as

AphasiaBrain NeoplasmsConnectomeGliomaDiffusion Tensor ImagingHumansLanguageTranscranial Magnetic StimulationconnectomeDTIGlioma-induced aphasiagraphic analysisnTMS

Identifiers

PMID34951084
PMCPMC8933329
OpenAlexW4200529264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.