Evidence map›Paper›PMID 34951063›Full record

Trial reportAnnals of neurology2022

Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial.

Martin E Johansson, Ian G M Cameron, Nicolien M Van der Kolk, Nienke M de Vries, Eva Klimars, Ivan Toni, Bastiaan R Bloem, Rick C Helmich

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06170866 (Peer Partners to Improve Physical Activity in Older Latino and Latina Adults With Parkinson's Disease.), which is not on this map. Cited by 183 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 16 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06170866 nacompletednot on this mapstarted 2023, after this paper: background citation

Peer Partners to Improve Physical Activity in Older Latino and Latina Adults With Parkinson's Disease.

TypeinterventionalSponsorUConn HealthRan2023 to 2024Enrolled10ConditionsParkinson DiseaseArmsSocially supported physical activity
3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 16 syntheses or guidelines pooled it, 264 citations in OpenAlex.

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  2. Altered regional spontaneous brain activity in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Martin E Johansson *Donders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-9778-6278
Ian G M Cameron *Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-1641-377X
Nicolien M Van der KolkDonders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4000-3735
Nienke M de VriesDonders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1972-2703
Eva KlimarsDonders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.
Ivan ToniDonders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-0936-3601
Bastiaan R BloemDonders Institute for Brain, Cognition and Behavior, Center for Medical Neuroscience, Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Center, Nijmegen, The Netherlands.
Rick C HelmichDonders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-4035-6573
Radboud University Nijmegen · NLHAN University of Applied Sciences · NL

Funding

BikevoorParkinsonZonMw
6 · The paper itself

Abstract

objectiveRandomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the corticostriatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects of aerobic exercise on tissue integrity of the substantia nigra, and on behavioral and cerebral indices of cognitive control.

methodsThe Park-in-Shape trial is a single-center, double-blind randomized controlled trial in 130 Parkinson's disease patients who were randomly assigned (1:1 ratio) to aerobic exercise (stationary home trainer) or stretching (active control) interventions (duration = 6 months). An unselected subset from this trial (exercise, n = 25; stretching, n = 31) underwent resting-state functional and structural magnetic resonance imaging (MRI), and an oculomotor cognitive control task (pro- and antisaccades), at baseline and at 6-month follow-up.

resultsAerobic exercise, but not stretching, led to increased functional connectivity of the anterior putamen with the sensorimotor cortex relative to the posterior putamen. Behaviorally, aerobic exercise also improved cognitive control. Furthermore, aerobic exercise increased functional connectivity in the right frontoparietal network, proportionally to fitness improvements, and it reduced global brain atrophy.

interpretationMRI, clinical, and behavioral results converge toward the conclusion that aerobic exercise stabilizes disease progression in the corticostriatal sensorimotor network and enhances cognitive performance. ANN NEUROL 2022;91:203-216.

Indexed as

ExerciseAgedBehaviorBrainCognitionDouble-Blind MethodExercise TherapyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetParkinson DiseaseProspective StudiesPsychomotor Performance

Identifiers

PMID34951063
PMCPMC9306840
OpenAlexW4200475539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.