Evidence map›Paper›PMID 34951008›Full record

ArticleJournal of the American Geriatrics Society2022

Prospective assessment of dementia on transitions in homeboundness using multistate Markov models.

Katherine A Ornstein, Shelley H Liu, Mohammed Husain, Claire K Ankuda, Evan Bollens-Lund, Amy S Kelley, Melissa M Garrido

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Incomplete Ascertainment of Mortality in a Nationally Representative Longitudinal Study of Community-Living Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  4. Article
  5. Article
  6. Study on Dynamic Progression and Risk Assessment of Metabolic Syndrome Based on Multi-State Markov Model.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katherine A OrnsteinDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-6270-4423
Shelley H LiuDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mohammed HusainDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0705-3343
Claire K AnkudaDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-1371-8524
Evan Bollens-LundDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8402-7635
Amy S KelleyDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-6345-9834
Melissa M GarridoDepartment of Health Law, Policy and Management, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-8986-3536

Funding

The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI William W.,MPH, MD Hung · 2010 to 2026
$21.9M
Home, but homebound: The impact of caregiving, financial, and community resources on the lives of individuals with dementiaR01AG060967 · NIA · JOHNS HOPKINS UNIVERSITY · PI ORNSTEIN, KATHERINE A · 2019 to 2023
$2.5M
The Burden of Care for Adults with Dementia: Impact on Care Quality and Family OutcomesR01AG054540 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLEY, AMY STEVES · 2017 to 2021
$2.1M
Health Care Use After Functional Disability: Opportunities to Improve the Care of Older AdultsK76AG064427 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANKUDA, CLAIRE KATHRYN · 2020 to 2024
$1.3M
Improving precision in modeling childhood executive function trajectories using psychometricsK25HD104918 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIU, SHELLEY HAN · 2021 to 2025
$651k
Midcareer Investigator Award for Patient-Oriented Research in Dementia and Serious IllnessK24AG062785 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLEY, AMY STEVES · 2019 to 2022
$581k
Endocrine disruptors and insulin resistance: quantifying impacts with a novel exposure burden scoreR03ES033374 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIU, SHELLEY HAN · 2021 to 2022
$185k
NIA NIH HHS K24 AG062785NIA NIH HHS K76 AG064427NIA NIH HHS P30 AG028741NIA NIH HHS R01 AG054540NIA NIH HHS R01 AG060967NIA NIH HHS U01 AG032947NICHD NIH HHS K25 HD104918NIEHS NIH HHS R03 ES033374
6 · The paper itself

Abstract

backgroundOne in 20 older adults in the United States is homebound and rarely/never leaves home. Although being homebound decreases the quality of the lived experience of individuals with serious illnesses, little is known about the frequency or likelihood of transitions in or out of homebound status. The objective of this study was to characterize the probability of transitions to and from homebound status among older adults and examine the relationship between dementia status and homebound transitions.

methodsUsing 2011-2018 data from the National Health and Aging Trends Study (NHATS), a nationally representative longitudinal study of aging in the United States, we identified 6375 community-dwelling Medicare beneficiaries. Homebound status (independent, semi-homebound (leaving home but with difficulty or help), homebound (rarely or never leaving home), nursing home resident, dead) was assessed annually via self-report. Transition probabilities across states were assessed using a multistate Markov model.

resultsLess than half of homebound individuals remain homebound (probability = 41.5% [95% CI: 39.2%, 43.5%]) after 1 year. One out of four dies (24% [22.3%, 26.0%]) and there is a low probability (3.2% [2.5%, 4.1%]) of transition to a nursing home. Dementia status was associated with increased risk of progression from independence to homebound status (HR: 1.83 [1.01, 3.34]). Dementia was consistently associated with increased probabilities of transitions to death including a two-fold increased hazards of progression from homebound to death (HR: 2.18 [1.69, 2.81]). Homebound individuals with dementia have a 34.2% [25.8%, 48.1%] probability of death in 5 years, compared with 17.4% [13.7%, 24.3%] among those without dementia. DISCUSSION: Dementia is associated with greater risk of transitioning across homebound states. There is a greater need to support home-based care for patients with dementia, especially as the ongoing COVID pandemic has raised concerns about the need to invest in alternative models to nursing home care.

Indexed as

COVID-19DementiaHomebound PersonsAgedHumansLongitudinal StudiesMedicareProspective StudiesUnited StatesdementiahomeboundMarkov models

Identifiers

PMID34951008
PMCPMC8986556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.