ArticleGeroScience2022
Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.
Article in GeroScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- Connecting memory and functional brain networks in older adults: a resting-state fMRI study.GeroScience · 2023Trial
- Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults.GeroScience · 2022Trial
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- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Neural Signatures of Engagement and Event Segmentation during Story Listening in Background Noise.eNeuro · 2026Article
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Progressive Changes Between Thalamic Nuclei and Cortical Networks Across Stimulus-Response Learning.Human brain mapping · 2025Article
- Diverse and distributed haemodynamic effects of theta burst stimulation in the prefrontal cortex.Neuroimage. Reports · 2025Article
- The association between fronto-insular interaction and executive function during childhood and adolescence in a resting state fMRI study.Scientific reports · 2025Article
- Executive Function Deficits in Genetic Frontotemporal Dementia: Results From the GENFI Study.Neurology. Genetics · 2025Article
- Brain functional connectivity characteristics at various levels of inhibitory function in elderly individuals with cognitive impairment.Scientific reports · 2025Article
- The unity/diversity framework of executive functions: behavioral and neural evidence in older adults.GeroScience · 2025Article
- Brain Resting-state Functional Connectivity Mediates the Age-associated Decline in Physical Activity Engagement.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes.GeroScience · 2025Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Cognitive and Neurobiological Correlates for Switching/Inhibition Moderate the Relations Between Word Reading and Reading Comprehension in Hebrew-Speaking Children: An fMRI Study.Dyslexia (Chichester, England) · 2025Article
- Socioeconomic Status, Trauma, Cognitive Function, Impulsivity, Reward Salience, and Future Substance Use: Role of Left Caudate Connectivity with the Cingulo-Opercular Network.Journal of cellular neuroscience · 2025Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Executive function is a cognitive domain that typically declines in non-pathological aging. Two cognitive control networks that are vulnerable to aging-the cingulo-opercular (CON) and fronto-parietal control (FPCN) networks-play a role in various aspects of executive functioning. However, it is unclear how communication within these networks at rest relates to executive function subcomponents in older adults. This study examines the associations between CON and FPCN connectivity and executive function performance in 274 older adults across working memory, inhibition, and set-shifting tasks. Average CON connectivity was associated with better working memory, inhibition, and set-shifting performance, while average FPCN connectivity was associated solely with working memory. CON region of interest analyses revealed significant connections with classical hub regions (i.e., anterior cingulate and anterior insula) for each task, language regions for verbal working memory, right hemisphere dominance for inhibitory control, and widespread network connections for set-shifting. FPCN region of interest analyses revealed largely right hemisphere fronto-parietal connections important for working memory and a few temporal lobe connections for set-shifting. These findings characterize differential brain-behavior relationships between cognitive control networks and executive function in aging. Future research should target these networks for intervention to potentially attenuate executive function decline in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.