Evidence map›Paper›PMID 34950968›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

A cross-scanner and cross-tracer deep learning method for the recovery of standard-dose imaging quality from low-dose PET.

Song Xue, Rui Guo, Karl Peter Bohn, Jared Matzke, Marco Viscione, Ian Alberts, Hongping Meng, Chenwei Sun, Miao Zhang, Min Zhang and 5 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Data-efficient generalization of AI transformers for noise reduction in ultra-fast lung PET scans.European journal of nuclear medicine and molecular imaging · 2025
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  9. Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.European journal of nuclear medicine and molecular imaging · 2025
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  10. Long-axial field-of-view PET/CT improves radiomics feature reliability.European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Review
  12. Article
  13. Sedation-free pediatric [European journal of nuclear medicine and molecular imaging · 2024
    Article
  14. IE-CycleGAN: improved cycle consistent adversarial network for unpaired PET image enhancement.European journal of nuclear medicine and molecular imaging · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Unified Noise-aware Network for Low-count PET Denoising with Varying Count Levels.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Song XueDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.
Rui GuoDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Karl Peter BohnDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.
Jared MatzkeDepartment of Informatics, Technical University of Munich, Munich, Germany.
Marco ViscioneDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.
Ian AlbertsDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.
Hongping MengDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chenwei SunDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Miao ZhangDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Min ZhangDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Raphael SznitmanARTORG Center, University of Bern, Bern, Switzerland.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Axel RomingerDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lb10363@rjh.com.cn.ORCID http://orcid.org/0000-0002-0493-2062
Kuangyu ShiDepartment of Nuclear Medicine, University of Bern, Bern, Switzerland.

Funding

shanghai municipal key clinical specialty shslczdzk03403Swiss National Science Foundation 188350Swiss National Science Foundation 188914
6 · The paper itself

Abstract

purposeA critical bottleneck for the credibility of artificial intelligence (AI) is replicating the results in the diversity of clinical practice. We aimed to develop an AI that can be independently applied to recover high-quality imaging from low-dose scans on different scanners and tracers.

methodsBrain [

resultsThe improvement achieved by AI recovery significantly correlated with the baseline image quality indicated by structural similarity index measurement (SSIM) (r = -0.71, p < 0.05) and normalized dose acquisition (r = -0.60, p < 0.05). Our cross-scanner and cross-tracer AI methodology showed utility based on both physical and clinical image assessment (p < 0.05).

conclusionThe deep learning development for extensible application on unknown scanners and tracers may improve the trustworthiness and clinical acceptability of AI-based dose reduction.

Indexed as

Deep LearningFluorodeoxyglucose F18Artificial IntelligenceBrainHumansImage Processing, Computer-AssistedPositron-Emission TomographyFluorodeoxyglucose F18Cross-scannerCross-tracerDeep learningLow-dosePETRecovery

Identifiers

PMID34950968
PMCPMC9015984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.