Evidence map›Paper›PMID 34950898›Full record

ArticlePatterns (New York, N.Y.)2021

Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction.

Saaket Agrawal, Marcus D R Klarqvist, Connor Emdin, Aniruddh P Patel, Manish D Paranjpe, Patrick T Ellinor, Anthony Philippakis, Kenney Ng, Puneet Batra, Amit V Khera

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Saaket AgrawalCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Marcus D R KlarqvistData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Connor EmdinCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Aniruddh P PatelCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Manish D ParanjpeCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Patrick T EllinorCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Anthony PhilippakisData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Kenney NgCenter for Computational Health, IBM Research, Cambridge, MA, USA.
Puneet BatraData Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Amit V KheraCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Broad Institute · USComputational Physics (United States) · US

Funding

MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Enabling improved applicability and transferability of polygenic scores across populationsU01HG011719 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI Alicia Martin · 2021 to 2026
$5.5M
Polygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NHLBI NIH HHS T32 HL007208
6 · The paper itself

Abstract

Current cardiovascular risk assessment tools use a small number of predictors. Here, we study how machine learning might: (1) enable principled selection from a large multimodal set of candidate variables and (2) improve prediction of incident coronary artery disease (CAD) events. An elastic net-based Cox model (ML4H

Indexed as

coronary artery diseaseFramingham risk scoremachine learningpooled cohort equationsQRISK3risk prediction

Identifiers

PMID34950898
PMCPMC8672148
OpenAlexW3204068536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.