Evidence map›Paper›PMID 34950896›Full record

ArticleCerebral circulation - cognition and behavior2021

An introduction to therapeutic approaches to vascular cognitive impairment.

Atticus H Hainsworth, Fanny M Elahi, Roderick A Corriveau

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

  1. The vascular contribution to dementia: World Stroke Organization scientific statement.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  2. The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  3. Article
  4. Review
  5. Dialysis and cognitive impairment.Nature reviews. Nephrology · 2025
    Review
  6. Review
  7. Review
  8. SDMA as a marker and mediator in cerebrovascular disease.Clinical science (London, England : 1979) · 2024
    Review
  9. Review
  10. Review
  11. Editorial.Cerebral circulation - cognition and behavior · 2024
    Article
  12. A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. PDE5 inhibitor drugs for use in dementia.Alzheimer's & dementia (New York, N. Y.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Atticus H HainsworthMolecular and Clinical Sciences Research Institute, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
Fanny M ElahiUCSF Weill Institute for Neurosciences, Memory and Aging Centre, San Francisco VA Health Care System, San Francisco, CA, United States.
Roderick A CorriveauNINDS, NIH, Bethesda, MD, United States.
National Institutes of Health · USSan Francisco VA Health Care System · USSt George's, University of London · GB

Funding

VCID Biomarkers Coordinating CenterU24NS100591 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Steven M Greenberg · 2016 to 2026
$19.8M
Medical Research Council MR/L023784/2Medical Research Council MR/R005567/1Medical Research Council MR/T033371/1NINDS NIH HHS U24 NS100591
6 · The paper itself

Abstract

Vascular cognitive impairment (VCI), encompassing vascular dementia, has been claimed as the "second-most common dementia" after Alzheimer Disease. Whether or not this is true, the clinical picture of most dementia in older people includes vascular disease. There are no validated pharmacological targets for prevention or treatment of VCI. This has inspired a multitude of potential treatment approaches, reflected by the articles in this Special Issue. These include

Indexed as

AD, Alzheimer's diseaseADRD, Alzheimer's disease and related dementiasClinical trialsDrugsFTD, frontotemporal dementiaLBD, dementia with Lewy bodiesNAPA, national plan to address Alzheimer's diseaseNIA, national institute on agingPD, Parkinson's diseaseSVD, small vessel diseaseTreatmentsVaD, vascular dementiaVascular cognitive impairmentVascular dementiaVCIDVCID, vascular contributions to cognitive impairment and dementia

Identifiers

PMID34950896
PMCPMC8661126
OpenAlexW3213308408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.