Observational studyNature cancer2021
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study.
Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph
Observational study in Nature cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03226886 (TRACERx Renal), which is not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
10.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRACERx Renal (TRAcking Renal Cell Carcinoma Evolution Through Therapy (Rx)) CAPTURE: COVID-19 Antiviral Response in a Pan-tumour Immune Study
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Seroconversion rate after COVID-19 vaccination in patients with solid cancer: A systematic review and meta-analysis.Human vaccines & immunotherapeutics · 2022Pooled it
- The prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis.Pathogens and global health · 2022Pooled it
- Immunogenicity and risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection after Coronavirus Disease 2019 (COVID-19) vaccination in patients with cancer: a systematic review and meta-analysis.European journal of cancer (Oxford, England : 1990) · 2022Pooled it
- A Systematic Review Assessing the Underrepresentation of Cancer Patients in COVID-19 Trials.Acta haematologica · 2022Pooled it
- Review
- Association of COVID-19 vaccines and antibody response in individuals with prior Coronavirus infection.Scientific reports · 2026Article
- Vaccination in Oncology Patients: Evidence, Clinical Challenges, and Future Directions.Vaccines · 2026Review
- Vaccination of patients with hematological malignancies: barriers and strategies to improve uptake.Frontiers in medicine · 2026Review
- Cracking the code of a correlate of protection against SARS-CoV-2 breakthrough infection in cancer patients.Scientific reports · 2025Article
- Article
- Immunogenicity of three-dose COVID-19 vaccines in people living with multiple sclerosis.BMJ neurology open · 2025Article
- Immunologic Predictors of Vaccine Responsiveness in Patients With Lymphoma and Chronic Lymphocytic Leukemia.The Journal of infectious diseases · 2024Article
- Herpes zoster after the third dose of SARS-CoV-2 mRNA-BNT162b2 vaccine in actively treated cancer patients: a prospective study.Clinical and experimental medicine · 2024Article
- mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer.Journal for immunotherapy of cancer · 2024Article
- COVID-19 in cancer patients: The impact of vaccination on outcomes early in the pandemic.Cancer medicine · 2023Article
- Effectiveness and safety of COVID-19 vaccines in patients with oncological diseases: State-of-the-art.World journal of clinical oncology · 2023Review
- Responses of patients with cancer to mRNA vaccines depend on the time interval between vaccination and last treatment.Journal for immunotherapy of cancer · 2023Article
- The immunogenicity of the ChAdOx1 nCoV-19 vaccination in participants with underlying comorbidity diseases: A prospective cohort study.Human vaccines & immunotherapeutics · 2023Article
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
97 authors at 4 institutions in 2 countries.
Annika Fendler *Cancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Scott T C Shepherd *Cancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Lewis Au *Cancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Katalin A Wilkinson *Tuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Mary Wu *Wellcome Center for Infectious Disease Research in Africa, University of Cape Town, Observatory, Cape Town, Republic of South Africa.
Fiona ByrneCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Maddalena CerroneTuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Andreas M SchmittSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Nalinie Joharatnam-HoganSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Benjamin ShumCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Zayd TippuSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Karolina RzeniewiczCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Laura Amanda BoosSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Ruth HarveyWorldwide Influenza Centre, The Francis Crick Institute, London, NW1 1AT, UK.
Eleanor CarlyleSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kim EdmondsSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lyra Del RosarioSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sarah SarkerSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Karla LingardSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Mary MangwendeSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lucy HoltSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Hamid AhmodSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Justine KortewegSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Tara FoleySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Jessica BazinHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
William GordonCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Taja BarberCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Andrea Emslie-HenryCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Wenyi XieCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Camille L GerardCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Daqi DengCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Emma C WallUniversity College London Hospitals NHS Foundation Trust Biomedical Research Centre, London, NW1 1AT, UK.
Ana Agua-DoceFlow Cytometry Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Sina NamjouSafety, Health & Sustainability, The Francis Crick Institute, London, NW1 1AT, UK.
Simon CaidanSafety, Health & Sustainability, The Francis Crick Institute, London, NW1 1AT, UK.
Mike GavrielidesScientific Computing Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
James I MacRaeMetabolomics Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Gavin KellyDepartment of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
Kema PeatSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Denise KellySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Aida MurraSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kayleigh KellySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Molly O'FlahertySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lauren DowdieSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Natalie AshSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Firza GronthoudDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Robyn L SheaDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Gail GardnerDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Darren MurrayDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Fiona KinnairdClinical Trials Unit, The Royal Marsden NHS Foundation Trust, London, SM2 5PT, UK.
Wanyuan CuiLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Javier PascualBreast Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Simon RodneySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Justin MencelGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Olivia CurtisLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Clemency StephensonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Anna RobinsonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Bhavna OzaSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sheima FaragSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Isla LeslieSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Aljosja RogiersSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sunil IyengarHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Mark EthellHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Christina MessiouDepartment of Radiology, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
David CunninghamGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Ian ChauGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Naureen StarlingGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Nicholas TurnerBreast Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Liam WelshNeuro-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Nicholas van AsClinical Oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Robin L JonesSarcoma Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, SW3 6JJ, UK.
Joanne DroneyPalliative Medicine, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Susana BanerjeeGynaecology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kate C TathamAnaesthetics, Perioperative Medicine and Pain Department, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Mary O'BrienLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kevin HarringtonHead and Neck, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Shreerang BhideHead and Neck, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Alicia OkinesBreast Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Alison ReidUro-oncology unit, The Royal Marsden NHS Foundation Trust, Surrey, SM2 5PT.
Kate YoungSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Andrew J S FurnessSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lisa PickeringSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Crick COVID19 consortium
Sonia GandhiNeurodegeneration Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Steve GamblinStructural Biology of Disease Processes Laboratory, The Francis Crick Institute, London, NW1 1AT, UK; Experimental Histopathology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
David Lv BauerRNA Virus Replication Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
George KassiotisRetroviral Immunology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Sacheen KumarGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Nadia YousafLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Shaman JhanjiAnaesthetics, Perioperative Medicine and Pain Department, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Emma NicholsonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Michael HowellHigh Throughput Screening Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Susanna WalkerAnaesthetics, Perioperative Medicine and Pain Department, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Robert J WilkinsonTuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
James LarkinSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Samra TurajlicCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Royal Marsden NHS Foundation Trust · GBThe Francis Crick Institute · GBUniversity of Cape Town · ZAUniversity College London Hospitals NHS Foundation Trust · GB
Funding
Cancer Research UK 18176Cancer Research UK 29911Cancer Research UK A18176Cancer Research UK FC001988Wellcome Trust FC001002Wellcome Trust FC001030Wellcome Trust FC001078Wellcome Trust FC001099Wellcome Trust FC001169Wellcome Trust FC001218Wellcome Trust FC001988Wellcome Trust FC011104
Abstract
CAPTURE (NCT03226886) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable neutralizing antibody titers (NAbT) against SARS-CoV-2 variants of concern (VOCs) vs wildtype (WT). Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT vs solid cancers against both WT and VOCs. In comparison with individuals without cancer, patients with haematological, but not solid, malignancies had reduced NAb responses. Seroconversion showed poor concordance with NAbT against VOCs. Prior SARS-CoV-2 infection boosted NAb response including against VOCs, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T-cell responses were detected in 80% of patients, and were comparable between vaccines or cancer types. Our results have implications for the management of cancer patients during the ongoing COVID-19 pandemic.
Indexed as
Adaptive ImmunityAdultAgedAged, 80 and overAntibodies, NeutralizingBNT162 VaccineCarcinoma, Renal CellChAdOx1 nCoV-19COVID-19COVID-19 VaccinesFemaleHumansImmunogenicity, VaccineKidney NeoplasmsLongitudinal StudiesMaleAntibodies, NeutralizingBNT162 VaccineChAdOx1 nCoV-19COVID-19 VaccinesAdaptive ImmunityAntibody ResponseCancerCOVID-19Neutralising AntibodiesProspective StudySARS-CoV-2T-cell ResponseVaccine
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Read underepoch 390
Registered trials
NCT03226886ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.