Evidence map›Paper›PMID 34950856›Full record

ArticleCardiology and cardiovascular medicine2021

Should We Operate on Thoracic Aortic Aneurysm of 5-5.5cm in Bicuspid Aortic Valve Disease Patients?

Katelyn Monaghan, Felix Orelaru, Aroma Naeem, Rana-Armaghan Ahmad, Xiaoting Wu, Karen M Kim, Shinichi Fukuhara, Himanshu J Patel, G Michael Deeb, Bo Yang

Open access · hybridAbstract read
In one paragraph

Article in Cardiology and cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katelyn MonaghanDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Felix OrelaruDepartment of General Surgery, St. Joseph Mercy, Ann Arbor, Michigan, USA.
Aroma NaeemDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Rana-Armaghan AhmadDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Xiaoting WuDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Karen M KimDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Shinichi FukuharaDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Himanshu J PatelDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
G Michael DeebDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Bo YangDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, Michigan, USA.
Michigan Medicine · USTrinity Health Ann Arbor Hospital · US

Funding

Therapeutic Insights into Loeys-Dietz Syndrome using Humanized ModelsR01HL151776 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bo Yang · 2020 to 2026
$4.2M
Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
Effect of mutations in the TGF-beta pathway genes on smooth muscle cell differentiation using patient derived iPSCs.K08HL130614 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2016 to 2020
$848k
NHLBI NIH HHS K08 HL130614NHLBI NIH HHS R01 HL141891NHLBI NIH HHS R01 HL151776
6 · The paper itself

Abstract

backgroundThis study aims to determine the long-term outcomes and rate of reoperation among BAV patients with aortic diameter of 5-5.5cm who underwent immediate surgical repair versus surveillance.

methodsA total of 148 BAV patients with aortic aneurysm measuring 5-5.5cm were identified between 1993 to 2019. Patients were categorized into two groups: immediately operated (n=89), versus watched group (n=59) i.e., monitored until either symptomatic, aortic diameter ≥ 5.5 cm or operated at surgeons' discretion/patient preference.

resultsCompared to the immediately operated group the watched group had significantly lower proportion of proximal aorta replacement (86% vs 100%). The mean size of proximal thoracic aorta at initial encounter, including aortic root, ascending, and arch, for the watched group was 52.1 ± 1.62mm and 52.6 ± 1.81mm in the immediately operated group, p=0.06. There was no significant difference in 10-year survival between the watched group 94% (95% CI: 79%, 99%) vs immediately operated group 96.5% (95% CI: 86%, 99%), p=0.90. Initial operation rate for the watched group during 10-year follow-up was 85%. The operative mortality in both groups was 0%. The 10-year reoperation rate between groups was similar: 3.5% (95% CI: 0.9%, 9.1%) in the immediately operated group vs 7.7% (95% CI: 2.4%, 17.1%) in the patients who eventually had surgery in the watched group, p= 0.30.

conclusionsOur study showed that the rate of reoperation was similar between groups and survival outcomes were acceptable in observed asymptomatic BAV patients without significant family history and with proximal aortic diameter of 5-5.5cm.

Indexed as

Bicuspid aortic valveLong-term outcomesThoracic aortic aneurysm

Identifiers

PMID34950856
PMCPMC8694044
OpenAlexW4200199662

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.