Evidence map›Paper›PMID 34950762›Full record

ArticleSSM - population health2021

Capturing the dynamic nature of stress exposure in the Pittsburgh Girls Study.

Kate Keenan, Haoyi Fu, Irene Tung, Johnny Berona, Robert T Krafty, Alison E Hipwell, Stephanie D Stepp, Kristen Carpio

Abstract read
In one paragraph

Article in SSM - population health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kate KeenanUniversity of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL, USA.
Haoyi FuUniversity of Pittsburgh, Department of Biostatistics, Pittsburgh, PA, USA.
Irene TungUniversity of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA.
Johnny BeronaUniversity of Chicago, Department of Psychiatry and Behavioral Neuroscience, Chicago, IL, USA.
Robert T KraftyEmory University, Department of Biostatistics & Bioinformatics, Atlanta, GA, USA.
Alison E HipwellUniversity of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA.
Stephanie D SteppUniversity of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA.
Kristen CarpioUniversity of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA.

Funding

The Development of Conduct Disorder in GirlsR01MH056630 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOEBER, ROLF · 1998 to 2012
$18.9M
Resilience to prenatal stress: Implications for offspring health and neurodevelopmentUH3OD023244 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALISON E HIPWELL · 2018 to 2026
$15.1M
Examining biomarkers and mechanisms of health disparities in sexual minority womenR01HL137246 · NHLBI · UNIVERSITY OF CHICAGO · PI KEENAN, KATHRYN ELIZABETH · 2017 to 2020
$3.2M
Maternal Stress Resilience During Pregnancy and Offspring Emotion RegulationK01MH123505 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUNG, IRENE · 2021 to 2025
$840k
NHLBI NIH HHS R01 HL137246NIH HHS UH3 OD023244NIMH NIH HHS K01 MH123505NIMH NIH HHS R01 MH056630
6 · The paper itself

Abstract

backgroundThe science of stress exposure and health in humans has been hampered by differences in operational definitions of exposures and approaches to defining timing, leading to results that lack consistency and specificity. In the present study we aim to empirically derive variability in type, timing and chronicity of stress exposure for Black and White females using prospectively collected data in the Pittsburgh Girls Study (PGS).

methodsThe PGS is an ongoing 20-year longitudinal, community-based study. In this paper we focused on annual caregiver reports of three domains of stress: subsistence (e.g., resource strain, overcrowding); safety (e.g., community violence, inter-adult aggression), and caregiving (e.g., separation, maternal depression) from early childhood through adolescence. Z-scores were used to conduct a finite mixture model-based latent class trajectory analysis. Model fit was compared using the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). We examined differences in timing and chronicity of stress exposure between Black and White girls.

resultsDistinct trajectory groups characterized by differential timing and chronicity of stress exposure were observed across all stress domains. Six trajectories characterized subsistence and safety stress, and five characterized caregiving stress. Variability in initial level, chronicity, and magnitude and timing of change was observed within and across domains of stressors. Race differences also varied across the domains: race differences in timing and chronicity were most pronounced for the subsistence and safety domains, whereas Black and White girls had similar levels of exposure to caregiving stress.

conclusionsSubstantial variability in timing and chronicity was observed within and across stress domains. Modeling specific domains and dimensions of stress exposure is likely important in testing associations between exposure and health; such specificity may lead to more effective deployment of preventive interventions based on stress exposure.

Indexed as

ChronicityDevelopmentExposurePGSStressTiming

Identifiers

PMID34950762
PMCPMC8671117

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.