Evidence map›Paper›PMID 34950689›Full record

ArticleFrontiers in nutrition2021

Whole Grain Qingke Attenuates High-Fat Diet-Induced Obesity in Mice With Alterations in Gut Microbiota and Metabolite Profile.

Xipu Li, Jingqi Suo, Xinguo Huang, Huifen Dai, Hongwu Bian, Muyuan Zhu, Weiqiang Lin, Ning Han

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Study on the Mechanism ofBiomolecules · 2026
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Gut microbiota is associated with response toEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
  9. Article
  10. Flavonoids fromFrontiers in nutrition · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xipu LiInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Jingqi SuoInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Xinguo HuangInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Huifen DaiThe Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Hongwu BianInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Muyuan ZhuInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Weiqiang LinInstitute of Translational Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ning HanInstitute of Genetic and Regenerative Biology, Key Laboratory for Cell and Gene Engineering of Zhejiang, College of Life Sciences, Zhejiang University, Hangzhou, China.
Zhejiang University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole grain Qingke (WGQK) displays anti-obesity and lipid-lowering properties; however, the underlying mechanism remains elusive. This study investigated the alteration of gut microbiota composition and metabolite profile induced by WGQK intervention in mice through the integration of 16S ribosomal RNA (rRNA) sequencing and an untargeted metabolomics study. C57BL/6J male mice were fed a normal control diet (NC), high-fat diet (HFD), and HFD plus 30% WGQK (HFD+QK) for 16 weeks. The WGQK intervention decreased body weight gain, glucose tolerance, and serum lipid levels, and alleviated liver function damage induced by HFD. Moreover, WGQK changed gut microbiota composition and enriched specific genera such as

Indexed as

CYP7A1fecal metabolitesFXRgut microbiotaobesitytryptophan metabolismunsaturated fatty acidswhole grain

Identifiers

PMID34950689
PMCPMC8688713
OpenAlexW4200596061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.