Evidence map›Paper›PMID 34950610›Full record

ArticleFrontiers in cellular and infection microbiology2021

Gut Microbiota Exceeds Cervical Microbiota for Early Diagnosis of Endometriosis.

Liujing Huang, Bingdong Liu, Zhihong Liu, Wanqin Feng, Minjuan Liu, Yifeng Wang, Dongxian Peng, Xiafei Fu, Honglei Zhu, Zongbin Cui and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 6 pooled it
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 6 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Liujing HuangDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Bingdong LiuGuangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
Zhihong LiuGuangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
Wanqin FengDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Minjuan LiuDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yifeng WangDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Dongxian PengDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xiafei FuDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Honglei ZhuDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zongbin CuiGuangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
Liwei XieDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Ying MaDepartment of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhujiang Hospital · CNSouthern Medical University · CNInstitute of Microbiology · CNGuangdong Academy of Sciences · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis of endometriosis is typically delayed by years for the unexclusive symptom and the traumatic diagnostic method. Several studies have demonstrated that gut microbiota and cervical mucus potentially can be used as auxiliary diagnostic biomarkers. However, none of the previous studies has compared the robustness of endometriosis classifiers based on microbiota of different body sites or demonstrated the correlation among microbiota of gut, cervical mucus, and peritoneal fluid of endometriosis, searching for alternative diagnostic approaches. Herein, we enrolled 41 women (control, n = 20; endometriosis, n = 21) and collected 122 well-matched samples, derived from feces, cervical mucus, and peritoneal fluid, to explore the nature of microbiome of endometriosis patients. Our results indicated that microbial composition is remarkably distinguished between three body sites, with 19 overlapped taxa. Moreover, endometriosis patients harbor distinct microbial communities versus control group especially in feces and peritoneal fluid, with increased abundance of pathogens in peritoneal fluid and depletion of protective microbes in feces. Particularly, genera of

Indexed as

EndometriosisGastrointestinal MicrobiomeMicrobiotaEarly DiagnosisFecesFemaleHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Sendometriosisgut microbiotaLachnospiraceae Ruminococcusperitoneal fluidPseudomonadaceae Pseudomonas

Identifiers

PMID34950610
PMCPMC8688745
OpenAlexW4200434679

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.