Evidence map›Paper›PMID 34950609›Full record

ArticleFrontiers in cellular and infection microbiology2021

HPV16-LINC00393 Integration Alters Local 3D Genome Architecture in Cervical Cancer Cells.

Xinxin Xu, Zhiqiang Han, Yetian Ruan, Min Liu, Guangxu Cao, Chao Li, Fang Li

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Applying 3D Genome Technology in Virology Research.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
  4. Article
  5. Viral remodeling of the 4D nucleome.Experimental & molecular medicine · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinxin XuDepartment of Obstetrics and Gynecology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Zhiqiang HanDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yetian RuanDepartment of Obstetrics and Gynecology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Min LiuDepartment of Obstetrics and Gynecology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Guangxu CaoDepartment of Obstetrics and Gynecology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Chao LiShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Fang LiDepartment of Obstetrics and Gynecology, East Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-risk human papillomavirus (hrHPV) infection and integration were considered as essential onset factors for the development of cervical cancer. However, the mechanism on how hrHPV integration influences the host genome structure remains not fully understood. In this study, we performed

Indexed as

Human papillomavirus 16Uterine Cervical NeoplasmsCarcinogenesisCell Line, TumorFemaleHumansVirus Integrationcervical cancergene expressionHi-CHPV integrationTAD boundary

Identifiers

PMID34950609
PMCPMC8691139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.