Evidence map›Paper›PMID 34950458›Full record

ArticleClinical kidney journal2021

Nicotinamide and acute kidney injury.

Miguel Fontecha-Barriuso, Ana M Lopez-Diaz, Sol Carriazo, Alberto Ortiz, Ana Belen Sanz

Registry-linked trialAbstract readEditorial
In one paragraph

Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07655791 (Evaluation of the Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07655791 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis

TypeinterventionalSponsorAin Shams UniversityRan2026 to 2027Enrolled60ConditionsSepsis - to Reduce Mortality in the Intensive Care UnitArmsNicotinamide 1000 mg
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Nicotinamide Attenuates Complement and Coagulation Pathways and Resultant Renal Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Nicotinamide Riboside, a Promising Vitamin BMolecules (Basel, Switzerland) · 2023
    Review
  15. Article
  16. Review
  17. Probiotics for kidney disease.Clinical kidney journal · 2022
    Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Miguel Fontecha-BarriusoLaboratory of Experimental Nephrology, Research Institute-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain.
Ana M Lopez-DiazLaboratory of Experimental Nephrology, Research Institute-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain.
Sol CarriazoLaboratory of Experimental Nephrology, Research Institute-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain.
Alberto OrtizLaboratory of Experimental Nephrology, Research Institute-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain.ORCID https://orcid.org/0000-0002-9805-9523
Ana Belen SanzLaboratory of Experimental Nephrology, Research Institute-Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent issue of

Indexed as

acute kidney injurychronic kidney diseaseNADnicotinamidetreatmentvitamin B3

Identifiers

PMID34950458
PMCPMC8690056

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.