Evidence map›Paper›PMID 34950450›Full record

ArticleClinical and translational allergy2021

Heterogeneous validity of daily data on symptoms of seasonal allergic rhinitis recorded by patients using the e-diary AllergyMonitor®.

Stephanie Dramburg, Serena Perna, Marco Di Fraia, Salvatore Tripodi, Stefania Arasi, Sveva Castelli, Danilo Villalta, Francesca Buzzulini, Ifigenia Sfika, Valeria Villella and 6 more

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Early Detection of Lower Adherence to Long-Term e-Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Stephanie DramburgDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.ORCID https://orcid.org/0000-0002-9303-3260
Serena PernaDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
Marco Di FraiaDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
Salvatore TripodiPediatric Allergology Unit Sandro Pertini Hospital Rome Italy.
Stefania ArasiDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.ORCID https://orcid.org/0000-0002-8135-0568
Sveva CastelliDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
Danilo VillaltaDepartment of Immunology-Allergy "S.Maria degli Angeli" Hospital Pordenone Italy.
Francesca BuzzuliniDepartment of Immunology-Allergy "S.Maria degli Angeli" Hospital Pordenone Italy.
Ifigenia SfikaPediatric Allergology Unit Sandro Pertini Hospital Rome Italy.
Valeria VillellaPediatric Allergology Unit Sandro Pertini Hospital Rome Italy.
Ekaterina PotapovaDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.
Maria Antonia BrighettiDepartment of Biology University of Rome "Tor Vergata" Rome Italy.
Alessandro TravagliniDepartment of Biology University of Rome "Tor Vergata" Rome Italy.
Pier Luigi VerardoCenter of Aerobiology ARPA Pordenone Italy.
Simone PelosiTPS Production S.r.l. Rome Italy.
Paolo Maria MatricardiDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin Berlin Germany.ORCID https://orcid.org/0000-0001-5485-0324
Humboldt-Universität zu Berlin · DEOspedale Sandro Pertini · ITAzienda Ospedaliera Santa Maria Degli Angeli · ITUniversity of Rome Tor Vergata · ITAlenia Aermacchi · ITT6 (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatient-generated symptom and medication scores are essential for diagnostic and therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different scores at population level in real-life data and trials. For clinicians, the evaluation of individual data quality over time is essential to decide whether to rely on these data in clinical decision-making.

objectiveTo analyze the consistency of different symptom (SS) and symptom medication scores (SMSs) at individual level in two study cohorts with different characteristics and explore individual patient trajectories over time.

methodsWithin the pilot phase of the @IT.2020 project on diagnostic synergy of mobile health and molecular IgE assessment in patients with SAR, we analyzed data of 101 children and 93 adults with SAR and instructed them to record their symptoms and medication intake daily via the mobile app AllergyMonitor®. We then assessed the correlation between different SMS and a visual analogue scale (VAS) on the impact of allergy symptoms on daily life at population and individual level.

resultsAt population level, the Rhinoconjunctivitis total symptom score (RTSS) correlated better with VAS than the combined symptom and medication score (CSMS). At individual level, consistency among RTSS and VAS was highly heterogeneous and unrelated to disease severity or adherence to recording. Similar heterogeneity was observed for CSMS and VAS.

conclusionsThe correlation of clinical information provided by different disease severity scores based on data collected via electronic diaries (e-diaries), is sufficient at population level, but broadly heterogeneous for individual patients. Consistency of the recorded data must be examined for each patient before remotely collected information is used for clinical decision making.

Indexed as

allergic rhinitismHealthpatient‐generated datapatient‐reported outcomessymptom scores

Identifiers

PMID34950450
PMCPMC8674539
OpenAlexW4200278720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.