Evidence map›Paper›PMID 34950395›Full record

ArticleThe Neurohospitalist2022

Case Report: Opsoclonus-Myoclonus Syndrome Associated With Contactin-Associated Protein-Like 2 and Acetylcholine Receptor Autoantibodies in the Setting of Non-Small Cell Lung Carcinoma.

Christian S Rosenow, Sara Dawit, Luca P Farrugia, Katharine A Henry Ma, Akanksha Sharma, Andrew McKeon, Alyx B Porter, Marie F Grill

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in The Neurohospitalist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christian S RosenowMayo Clinic Alix School of Medicine, Scottsdale, AZ, USA.ORCID https://orcid.org/0000-0003-1205-4906
Sara DawitDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Luca P FarrugiaMayo Clinic Alix School of Medicine, Scottsdale, AZ, USA.
Katharine A Henry MaMayo Clinic Alix School of Medicine, Scottsdale, AZ, USA.
Akanksha SharmaDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.ORCID https://orcid.org/0000-0002-4331-5526
Andrew McKeonDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Alyx B PorterDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Marie F GrillDepartment of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
Mayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opsoclonus myoclonus syndrome (OMS) is a rare immune-mediated paraneoplastic or para/-post-infectious syndrome characterized by "dancing" eye movements, myoclonus, and ataxia. Neuropsychiatric symptoms have also been reported. Without treatment, OMS may progress to further neurological impairment and even death. Autoimmune attack of CNS structures in OMS is most commonly mediated by anti-Ri (also known as ANNA2) IgG antibodies, with additional findings implicating antibodies targeting various neurotransmitter receptors. Prompt immunotherapy and neoplasm treatment may result in improvement. We report a novel association of Contactin-Associated Protein-Like 2 (Caspr2) antibodies occurring in association with paraneoplastic OMS. While breast cancer and small cell lung cancer (SCLC) are more commonly associated with OMS among adults, we characterize a novel association between Caspr2 antibody in a patient with mixed non-small cell and small cell lung carcinoma.

Indexed as

autoimmune diseases of the nervous systemclinical specialtycranial nerve diseasesnervous systemnervous system neoplasmsneuroimmunologyneurooncologyopsoclonus-myoclonus syndromeparaneoplastic syndromes

Identifiers

PMID34950395
PMCPMC8689548
OpenAlexW3160473424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.