ArticleJournal of atrial fibrillation
High Brain Natriuretic Peptide Level Predicts The Prevalence Of Low-Voltage Areas And Poor Rhythm Outcome In Patients Undergoing Atrial Fibrillation Ablation.
Article in Journal of atrial fibrillation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Atrial to brain natriuretic peptide ratio as a marker of atrial remodeling severity and post-ablation recurrence risk in atrial fibrillation patients with left atrial enlargement.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Association between body size and atrial myopathy: Investigation using the prevalence of left atrial low-voltage areas.Heliyon · 2025Article
- Research Progress of Low-Voltage Areas Associated with Atrial Fibrillation.Reviews in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsThe prevalence of residual left atrial low-voltage areas (LVAs) is associated with atrial fibrillation (AF) recurrence after pulmonary vein isolation. Brain natriuretic peptide (BNP) may be increased in AF patients and may raise AF recurrence risk after catheter ablation. We investigated the association between BNP and the prevalence of LVAs.
methodsOne hundred and eighty three consecutive AF cases were retrospectively enrolled that underwent initial ablation for AF (persistent AF, 82 [45%] patients). Serum BNP was measured before ablation and the natural logarithm of BNP (log-BNP) was calculated. Low-voltage points were defined as sites with left atrial electrogram amplitude <0.5 mV. LVAs were defined as regions with ≥5% low-voltage points across the total surface area of the left atrium.
resultsOf the 183 patients, 38 (21%) had LVAs. Patients with LVAs demonstrated higher log-BNP (4.8±0.9 vs. 3.9±1.2, P<0.001). The optimal cut-off value of log-BNP was 4.4, which was equivalent to 81 pg/mL of BNP. LVAs were more frequent in patients with higher log-BNP. In multivariate analysis, log-BNP >4.4 was an independent predictor of LVAs (odds ratio 2.7 [95% confidence interval 1.01-7.1], P=0.048). Freedom from AF recurrence was significantly lower in patients with than without high log-BNP (P=0.007).
conclusionsBNP correlated with the prevalence of left atrial LVAs and AF recurrence in patients with AF undergoing catheter ablation.
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