Evidence map›Paper›PMID 34950225›Full record

ArticleResearch in autism spectrum disorders2021

Direct observation in a large-scale randomized trial of parent training in children with autism spectrum disorder and disruptive behavior.

Naomi Swiezy, Tristam Smith, Cindy R Johnson, Karen Bearss, Luc Lecavalier, Rochelle Drill, Danielle Warner, Yanhong Deng, Yunshan Xu, James Dziura and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in autism spectrum disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Naomi SwiezyDepartment of Psychiatry, HANDS in Autism® Interdisciplinary Training and Resource Center, Indiana University School of Medicine, Indianapolis, IN; HANDS in Autism®, Indiana University School of Medicine, 1002 Wishard Drive, Suite 1021, Indianapolis, IN 46202.
Tristam SmithDepartment of Pediatrics, University of Rochester, Rochester, NY; University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642.
Cindy R JohnsonCleveland Clinic Children's, Lerner College of Medicine at Case Western Reserve University, Cleveland, OH; Center for Autism, Cleveland Clinic Children's, 2801 MLK Jr. Drive, Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44101.
Karen BearssDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA; Seattle Children's Autism Center and Research Institute, 4909 25th Avenue, Northeast, Seattle, Washington, 98105; University of Washington, Department of Psychiatry and Behavioral Sciences, 1959 Northeast Pacific Street, Seattle, Washington 98195.
Luc LecavalierDepartments of Psychology and Psychiatry, Nisonger Center, UCEDD, Ohio State University, Columbus, OH; Ohio State University, Nisonger Center, UCEDD, 371-D McCampbell Hall, 1581 Dodd Drive Columbus, Ohio 43210.
Rochelle DrillCenter for Assessment and Treatment, Chevy Chase, MD; Center for Assessment and Treatment; 8401 Connecticut Avenue, Suite 1000 Chevy Chase, MD 20815.
Danielle WarnerIndependent Scholar.
Yanhong DengSchool of Public Health, Yale University, New Haven, CT; School of Public Health, Yale University, 300 George street, Suite 511, New Haven, CT 06520.
Yunshan XuSchool of Public Health, Yale University, New Haven, CT; School of Public Health, Yale University, 300 George street, Suite 511, New Haven, CT 06520.
James DziuraDepartment of Emergency Medicine, Yale University, New Haven, CT; Department of Emergency Medicine, Yale University, 464 Congress Ave, New Haven, CT, 06519.
Ben HandenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA; Western Psychiatric Hospital, 3811 O'Hara St., Pittsburgh PA 15213.
Lawrence ScahillDepartment of Pediatrics, Marcus Autism Center, Children's Healthcare of Atlanta and Emory, Atlanta, GA; Emory University School of Medicine, Department of Pediatrics, Marcus Autism Center, 1920 Briarcliff Road NE, Atlanta, Georgia 30329.
Yale University · USCenter for Assessment · USCleveland Clinic · USEmory University · USFilm Independent · USIndiana University School of MedicineThe Ohio State University · USUniversity of Pittsburgh · USUniversity of Rochester Medical Center · USUniversity of Washington · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
1/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081148 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2010 to 2014
$1.8M
3/5-Randomized Trial of Parent Training for Young Children with AutismR01MH080906 · NIMH · UNIVERSITY OF ROCHESTER · PI SMITH, TRISTRAM H · 2010 to 2014
$1.2M
5/5-Randomized Trial of Parent Training for Young Children with AutismR01MH080965 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, CYNTHIA R · 2010 to 2014
$1.2M
4/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081221 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI SWIEZY, NAOMI BETH · 2010 to 2014
$1.2M
2/5-Randomized Trial of Parent Training for Young Children with AutismR01MH081105 · NIMH · OHIO STATE UNIVERSITY · PI LECAVALIER, LUC · 2010 to 2014
$1.1M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH080906NIMH NIH HHS R01 MH080965NIMH NIH HHS R01 MH081105NIMH NIH HHS R01 MH081148NIMH NIH HHS R01 MH081221
6 · The paper itself

Abstract

A direct observation strategy (Standardized Observation Analogue Procedure, SOAP) was used in a large-scale randomized trial of parent training versus parent education in young children with autism spectrum disorder (ASD) and disruptive behavior. The 16-minute SOAP, modified from an earlier version of this same measure, included parentchild interaction to assess child behavior in a clinical laboratory setting. Despite study entry criteria for all child participants requiring moderate levels of disruptive behavior in this project, 126 of 168 children with complete SOAP data at baseline showed no disruptive behavior on this measure. Although the primary purpose of the study was to determine whether the SOAP could detect differences between the two conditions (i.e.,parent training (PT) and parent education (PE)), baseline observation data was not consistent with parent ratings at baseline or subsequent follow up visits, leaving little room to demonstrate improvement with this observation measure. This and the challenging, time-consuming and resource intensive effort involved in using such a measure in a large randomized scale trial, raises fundamental questions about the validity of the SOAP as an outcome measure in such a study. Further consideration related to the feasibility and practicality of using direct observation as a primary measure in larger scale efforts overall are also discussed.

Indexed as

AssessmentAutism spectrum disorder (ASD)Behavioralbehavioral interventiondirect observationparent and caregiver trainingRandomized Control Trial (RCT)

Identifiers

PMID34950225
PMCPMC8691726
OpenAlexW3213283439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.