Evidence map›Paper›PMID 34950221›Full record

Trial reportComputational and mathematical methods in medicine2021

Effect of Xiaoyutang Combined with Intraperitoneal Heat Perfusion Chemotherapy on Immune Function, Circulating mir, Prognosis, and Survival of Postoperative Patients with Colorectal Cancer.

Lingxia Li, Yunjiu Wang, Xiaowan Huang, Jian Sun, Jue Zhang

RetractedOpen access · hybridAbstract readRandomized Controlled TrialRetracted Publication
In one paragraph

Trial report in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Clinical Observation of Fuzheng Xiaoji Granule in the Treatment of Stage IIIC Colorectal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lingxia LiShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China.
Yunjiu WangShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China.
Xiaowan HuangShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China.
Jian SunShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China.ORCID https://orcid.org/0000-0001-9645-4741
Jue ZhangShuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China.ORCID https://orcid.org/0000-0002-4642-8948
Shanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the effects of Xiaoyutang combined with intraperitoneal heat perfusion chemotherapy on immune function, circulating Mir, and prognosis and survival of postoperative patients with colorectal cancer.

methodsA total of 96 patients with colorectal cancer who were treated in our hospital from May 2018 to August 2019 and followed up to August 2021 were selected as the study subjects. The patients were randomly divided into a control group and study group by a 1 : 1 random number table method, 48 cases in each group. Patients in the control group were given intraperitoneal thermal perfusion chemotherapy after surgery, and patients in the research group were treated with Xiaoyutang on this basis. The treatment cycle was 21 days, and all patients were treated for 3 consecutive cycles. The therapeutic efficacy, immune function (CD3

resultsAfter 3 cycles of treatment, ORR and DCR in the study group were higher than those in the control group (60.42% vs. 37.50%) and 85.42% vs. 66.67%, respectively, with statistical significance (

conclusionXiaoyutang combined with peritoneal heat perfusion chemotherapy has a good postoperative effect on patients with colorectal cancer, which can effectively improve the immune function and circulating Mir of patients with colorectal cancer, reduce tumor recurrence, and improve the prognosis of patients.

Indexed as

Hyperthermic Intraperitoneal ChemotherapyAntineoplastic Combined Chemotherapy ProtocolsChinaColorectal NeoplasmsCombined Modality TherapyComputational BiologyDrugs, Chinese HerbalFemaleHumansKaplan-Meier EstimateMaleMicroRNAsMiddle AgedPostoperative PeriodPrognosisDrugs, Chinese HerbalMicroRNAsMIRN145 microRNA, humanMIRN29a microRNA, humanMIRN92 microRNA, human

Identifiers

PMID34950221
PMCPMC8691972
OpenAlexW4200550053

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.