Evidence map›Paper›PMID 34950033›Full record

ArticleFrontiers in pharmacology2021

Jing Tang, Xiaolan Cheng, Shiyu Yi, Yuanyuan Zhang, Zhigang Tang, Yutong Zhong, Qiuping Zhang, Bin Pan, Yubin Luo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. 7-azaindole as privileged scaffold: Advances in drug design and structural modification.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jing TangLaboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Sichuan, China.
Xiaolan ChengAffiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Shiyu YiDepartment of Rheumatology and Immunology, The General Hospital of Western Theater Command PLA, Chengdu, China.
Yuanyuan ZhangSichuan Food and Drug Inspection and Testing Institute, Chengdu, China.
Zhigang TangLaboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Sichuan, China.
Yutong ZhongLaboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Sichuan, China.
Qiuping ZhangLaboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Sichuan, China.
Bin PanShandong Peninsula Engineering Research Center of Comprehensive Brine Utilization, Weifang University of Science and Technology, Shouguang, China.
Yubin LuoLaboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Sichuan, China.
Sichuan University · CNNanjing University of Chinese Medicine · CNWeifang University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll like receptor (TLR)s have a central role in regulating innate immunity and their activation have been highlighted in the pathogenesis of rheumatoid arthritis (RA). EFL2, one of diterpenoids derived from

Indexed as

euphorbia factor L2IRF5rheumatoid arthritisserum-induced arthritisTLR7

Identifiers

PMID34950033
PMCPMC8691750
OpenAlexW4200325247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.