ArticleProceedings of the National Academy of Sciences of the United States of America1987
Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 203 citations in OpenAlex.
- The tolerability of continuous intravenous infusion of interleukin-3 after DHAP chemotherapy in patients with relapsed malignant lymphoma. A phase-I study.Annals of hematology · 1993Trial
- Article
- Mechanisms of Sustained Neutrophilia in Patient WHIM-09, Cured of WHIM Syndrome by Chromothripsis.Journal of clinical immunology · 2018Article
- Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.Nature immunology · 2009Article
- Integrin-mediated protein kinase A activation at the leading edge of migrating cells.Molecular biology of the cell · 2008Article
- Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL.Leukemia · 2004Article
- Elevated IL-5 levels in pleural fluid of patients with paragonimiasis westermani.Clinical and experimental immunology · 2001Article
- New Light Shed On The Enigmatic Eosinophil Granulocyte; A Versatile Cell Of The Immune System.EJIFCC · 1999Review
- Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice.The Journal of clinical investigation · 1998Article
- Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.Molecular and cellular biology · 1996Article
- Article
- Effect of IL-4 and interferon-gamma (IFN-gamma) on IL-3- and IL-5-induced eosinophil differentiation from human cord blood mononuclear cells.Clinical and experimental immunology · 1995Article
- Role of interleukin-5 in enhanced migration of eosinophils from airways of immunized guinea-pigs.British journal of pharmacology · 1994Article
- Retroviral mediated gene transfer in megakaryocytic cell lines.In vitro cellular & developmental biology. Animal · 1994Article
- 1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant.Journal of clinical immunology · 1994Article
- Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites.The Journal of experimental medicine · 1993Article
- Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice.British journal of pharmacology · 1993Article
- A human interleukin 3 analog with increased biological and binding activities.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Interleukin-3-induced up-regulation of CR3 expression on human eosinophils is inhibited by dexamethasone.Immunology · 1992Article
- Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro.Clinical and experimental immunology · 1991Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cloned gibbon interleukin 3 (gIL-3) was found to stimulate the proliferation and differentiation of human bone marrow cells to produce day-14 granulocyte, macrophage, granulocyte-macrophage, and eosinophil colonies in semisolid agar. In the presence of normal human plasma, gIL-3 stimulated megakaryocytes. In methylcellulose cultures, it stimulated erythroid colonies in the presence, but not in the absence, of erythropoietin. When mature human leukocytes were used, gIL-3 stimulated the function of purified mature eosinophils as measured by the capacity to kill antibody-coated target cells, to produce superoxide anions, and to phagocytize opsonized yeast particles in a manner similar to recombinant human granulocyte-macrophage colony-stimulating factor. In contrast, gIL-3 did not significantly stimulate any of the neutrophil functions tested, whereas human recombinant granulocyte-macrophage colony-stimulating factor was active in these assays. Among cytokines that are active on human hematopoietic cells, gIL-3 thus has a distinct set of functions and may predict the range of actions of the human molecule.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.