Evidence map›Paper›PMID 34949964›Full record

ArticleGenetics research2021

Frequencies of CYP2B6

Mohammad Bagher Hashemi-Soteh, Elaheh Hosseini, Shokoufeh Fazelnia, Faramarz Ghasemian-Sorbeni, Sara Madahian, Mohammad Reza Shiran

Open access · goldAbstract read
In one paragraph

Article in Genetics research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mohammad Bagher Hashemi-SotehImmunogenetic Research Center, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0001-5361-520X
Elaheh HosseiniNovin Genetic Diagnostic Laboratory, FarahAbad Boulevard, Sari, Mazandaran, Iran.ORCID 0000-0002-7648-9610
Shokoufeh FazelniaNovin Genetic Diagnostic Laboratory, FarahAbad Boulevard, Sari, Mazandaran, Iran.
Faramarz Ghasemian-SorbeniNovin Genetic Diagnostic Laboratory, FarahAbad Boulevard, Sari, Mazandaran, Iran.ORCID 0000-0002-1005-1819
Sara MadahianNovin Genetic Diagnostic Laboratory, FarahAbad Boulevard, Sari, Mazandaran, Iran.
Mohammad Reza ShiranThe Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The human CYP2B subfamily consists of one functional gene (CYP2B6) and one pseudogene (CYP2B7P). Cytochrome P450 2B6 (CYP2B6) is a highly polymorphic enzyme that shows marked interindividual and interethnic variations. Currently, 38 alleles have been described, and some of the allelic variants have been associated with low enzyme activity. The aim of this study was to investigate the frequencies of CYP2B6 Methods: The study was conducted in 289 unrelated healthy volunteers. DNA was extracted from peripheral blood and analyzed by the PCR-RFLP protocol. The PCR product was digested with restriction enzymes and then separated using agarose gel electrophoresis. Results: The frequency of CYP2B6 Conclusion: The frequency of the CYP2B6

Indexed as

Cytochrome P-450 CYP2B6AllelesGene FrequencyGenetics, PopulationGenotypeHumansIranCYP2B6 protein, humanCytochrome P-450 CYP2B6

Identifiers

PMID34949964
PMCPMC8660211
OpenAlexW4200411509

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.