Evidence map›Paper›PMID 34949923›Full record

ArticleInternational journal of nanomedicine2021

Development of Chitosan-Based Nanoemulsion Gel Containing Microbial Secondary Metabolite with Effective Antifungal Activity: In vitro and in vivo Characterizations.

Muhammad Khalid Khan, Barkat Ali Khan, Bushra Uzair, Shah Iram Niaz, Haroon Khan, Khaled Mohamed Hosny, Farid Menaa

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

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  6. RETRACTED:Pharmaceutics · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Muhammad Khalid KhanDrug Delivery and Cosmetics Laboratory (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan.
Barkat Ali KhanDrug Delivery and Cosmetics Laboratory (DDCL), Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan.
Bushra UzairDepartment of Biotechnology and Bioinformatics, International Islamic University, Islamabad, 40000, Pakistan.ORCID 0000-0003-2181-6378
Shah Iram NiazDepartment of Chemistry, Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, 29050, Pakistan.
Haroon KhanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Pakistan.
Khaled Mohamed HosnyDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Farid MenaaDepartment of Nanomedicine, California Innovations Corporation, San Diego, CA, 92037, USA.
Gomal University · PKCalifornia Medical Innovations Institute · USInternational Islamic University, Islamabad · PKKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMicrobial resistance to antibiotics is one of the most important public health concerns of the 21

methodsThree compounds were isolated and purified of which only one compound (Pure 2) showed potent antifungal activity (MFC: 8-132 µg/mL), which was also significantly (

resultsNMR analyses identified the compound as a derivative of phthalic acid ester (PAE). The optimized formulations displayed a droplet size <100 nm, -ve zeta potential, and PDI <0.45. The drug content was within the official limit of pharmacopeia (ie, 100±10%). Insignificant changes (

conclusionHence, the NEG-loaded PAE isolated from

Indexed as

Antifungal AgentsChitosanAdministration, CutaneousAnimalsEmulsionsParticle SizeRabbitsAntifungal AgentsChitosanEmulsionsfungal resistancemicrobial secondary metabolitesnanoemulsion gelphthalic acid ester derivativePseudomonas fluorescensred soil

Identifiers

PMID34949923
PMCPMC8689013
OpenAlexW4200578868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.