Evidence map›Paper›PMID 34949913›Full record

ArticleDrug design, development and therapy2021

Bio-Guided Isolation of Two New Hypoglycemic Triterpenoid Saponins from

Doudou Huang, Zenan Du, Yanhong Chen, Zhiying Dong, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen, Lianna Sun

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Ultrasound-Assisted Enzymatic Extraction of Mangiferin From Mango (Journal of analytical methods in chemistry · 2025
    Article
  3. Molecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Doudou Huang *Department of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Zenan Du *Department of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Yanhong Chen *Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Zhiying DongDepartment of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Xiujuan WangDepartment of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Mengshuang LiDepartment of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Feng Zhang *Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Wansheng ChenInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Lianna SunDepartment of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Shanghai University of Traditional Chinese Medicine · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetes is a common disease caused by a combination of genetic and environmental factors, which was the top three diseases threatening human health. Therefore, it is necessary to seek more efficient hypoglycemic drugs. The main objective of this study was to investigate the potential hypoglycemic effects of compounds from MATERIALS AND

methodsOur experiments were divided into three steps: (1) α-amylase test and oral starch tolerance test (OSTT) for screening the biological extract part of

resultsThe n-butanol fractioned part of

conclusionTwo new triterpenoid saponins were firstly isolated from

Indexed as

Drugs, Chinese HerbalHypoglycemic AgentsMolecular Docking SimulationPlant ExtractsPolygonumSaponinsTriterpenesDrugs, Chinese HerbalHypoglycemic AgentsPlant ExtractsSaponinsTriterpeneshypoglycemicPolygonum capitatumtriterpene saponinsα-amylase

Identifiers

PMID34949913
PMCPMC8689516
OpenAlexW4200467977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.