Evidence map›Paper›PMID 34949875›Full record

ArticleBiometrika2021

Maximum Likelihood Estimation for Semiparametric Regression Models With Panel Count Data.

By Donglin Zeng, D Y Lin

Abstract read
In one paragraph

Article in Biometrika, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Checking the Cox Proportional Hazards Model with Interval-Censored Data.Journal of the American Statistical Association · 2025
    Article
  2. Post-selection inference for the Cox model with interval-censored data.Scandinavian journal of statistics, theory and applications · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

By Donglin ZengDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7420, USA.
D Y LinDepartment of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7420, USA.

Funding

Semiparametric Analysis of Big Censored DataR01HL149683 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2020 to 2023
$1.9M
Statistical Methods in Trans-Omics Chronic Disease ResearchR01HG009974 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, DANYU · 2018 to 2022
$1.5M
NHGRI NIH HHS R01 HG009974NHLBI NIH HHS R01 HL149683
6 · The paper itself

Abstract

Panel count data, in which the observation for each study subject consists of the number of recurrent events between successive examinations, are commonly encountered in industrial reliability testing, medical research, and various other scientific investigations. We formulate the effects of potentially time-dependent covariates on one or more types of recurrent events through non-homogeneous Poisson processes with random effects. We adopt nonparametric maximum likelihood estimation under arbitrary examination schemes and develop a simple and stable EM algorithm. We show that the resulting estimators of the regression parameters are consistent and asymptotically normal, with a covariance matrix that achieves the semiparametric efficiency bound and can be estimated through profile likelihood. We evaluate the performance of the proposed methods through extensive simulation studies and present a skin cancer clinical trial.

Indexed as

EM algorithminterval censoringnon-homogeneous Poisson processnonparametric likelihoodproportional means modelrandom effectsrecurrent eventssemiparametric efficiencytime-dependent covariates

Identifiers

PMID34949875
PMCPMC8691743

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.