ArticleNature immunology2022
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4
Erratum issuedAbstract read
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Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 99 citations in OpenAlex.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- The role of mTORC2/RICTOR in immune cells and inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- ALOX15 orchestrates mitochondrial antiviral immunity and serves as a host target for anti-influenza therapy.Nature immunology · 2026Article
- Non-canonical role of "S6K1-SGK1" pathway in neuronal necroptosis following traumatic brain injury.Genes & diseases · 2026Article
- Article
- Viral-host interactions mediated by the mTOR signaling pathway.Cell insight · 2026Review
- GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression.Cellular & molecular immunology · 2026Article
- Iron status modulates immune cell proportions to drive epigenetic age acceleration: A 2-step Mendelian randomization study.Medicine · 2026Article
- Epigenetic and post-translational regulatory networks of ferroptosis in the tumor immune microenvironment.Experimental hematology & oncology · 2026Review
- Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026Review
- Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy.International journal of biological sciences · 2026Review
- The ferroptosis-ncRNA-exosome triad: key orchestrators in cancer immunopathogenesis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Ferroptosis: unveiling a transformative perspective in the landscape of autoimmune diseases.Frontiers in immunology · 2026Review
- Review
- Amino acid-dependent TSC2 dephosphorylation by lysosome-PP2A regulates mTORC1 signaling transduction.Life science alliance · 2025Article
- Review
- Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy.Molecular cancer · 2025Review
- Molecular mechanisms of immune cell death in immunosenescence.Cell death and differentiation · 2025Review
- Immunosenescence: signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
23 authors at 5 institutions in 1 country.
Yifei Wang *Guangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
Qin Tian *Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-7681-2115
Yaxing Hao *Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Wei YaoInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Jinjin LuGuangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
Cheng ChenInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Xiangyu ChenGuangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
Yao LinInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Qizhao HuangGuangdong Province Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China.
Lifan XuInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Jianjun HuInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Shun LeiInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Zhengping WeiInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Yuan LuoInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Zhirong LiInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Li HuInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Jianfang TangInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Qing WuInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.
Xinyuan ZhouInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-1374-8240
Yuzhang WuInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-5948-1596
Zhinan YinGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, China. tzhinan@jnu.edu.cn.ORCID http://orcid.org/0000-0001-6524-8777
Jianqing XuShanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital & Institutes of Biomedical Sciences, Fudan University, Shanghai, China. xujianqing@fudan.edu.cn.ORCID http://orcid.org/0000-0003-0896-9273
Lilin YeInstitute of Immunology, PLA, Third Military Medical University, Chongqing, China. yelilinlcmv@tmmu.edu.cn.ORCID http://orcid.org/0000-0003-0778-3311
Army Medical University · CNSouthern Medical University · CNFirst Affiliated Hospital of Jinan University · CNJinan University · CNSun Yat-sen University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antigen-specific memory CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesFerroptosisGlycogen Synthase Kinase 3 betaImmunologic MemoryLipid PeroxidationLongevityLymphocyte ActivationLymphocyte CountLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLProto-Oncogene Proteins c-aktGlycogen Synthase Kinase 3 betaMechanistic Target of Rapamycin Complex 2Proto-Oncogene Proteins c-akt
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.