Evidence map›Paper›PMID 34949831›Full record

ReviewNature reviews. Urology2022

The placebo and nocebo effects in functional urology.

Hadi Mostafaei, Sandra Jilch, Greta Lisa Carlin, Keiichiro Mori, Fahad Quhal, Benjamin Pradere, Ekaterina Laukhtina, Victor M Schuettfort, Abdulmajeed Aydh, Reza Sari Motlagh and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Interstitial cystitis-an imbalance of risk and protective factors?Frontiers in pain research (Lausanne, Switzerland) · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hadi MostafaeiDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5596-1771
Sandra JilchDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Greta Lisa CarlinDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Keiichiro MoriDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Fahad QuhalDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Benjamin PradereDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-7768-8558
Ekaterina LaukhtinaDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-8953-0272
Victor M SchuettfortDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Abdulmajeed AydhDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-6078-6816
Reza Sari MotlaghDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Claus G RoehrbornDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shahrokh F ShariatDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. shahrokh.shariat@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-6627-6179
Sakineh HajebrahimiResearch Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0003-1494-7097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A placebo is an inert substance normally used in clinical trials for comparison with an active substance. However, a placebo has been shown to have an effect on its own; commonly known as the placebo effect. A placebo is an essential component in the design of conclusive clinical trials but has itself become the focus of intense research. The placebo effect is partly the result of positive expectations of the recipient on the state of health. Conversely, a nocebo effect is when negative expectations from a substance lead to poor treatment outcomes and/or adverse events. Randomized controlled trials in functional urology have demonstrated the importance of the placebo and nocebo effects across different diseases such as overactive bladder, urinary incontinence, lower urinary tract symptoms and interstitial cystitis/painful bladder syndrome, as well as male and female sexual dysfunction. Understanding the true nature of the placebo-nocebo complex and the scope of its effect in functional urology could help urologists to maximize the positive effects of this phenomenon while minimizing its potentially negative effects.

Indexed as

Lower Urinary Tract SymptomsUrologyFemaleHumansMaleNocebo EffectPlacebo EffectTreatment Outcome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.