ArticleNature ecology & evolution2022
A masculinizing supergene underlies an exaggerated male reproductive morph in a spider.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Crossing experiments suggest a simple genetic basis of complex male self-sacrifice phenotypes in widow spiders.Biology letters · 2026Article
- Multiple Origins of a Sex Ratio Supergene in Formica Ants.Molecular biology and evolution · 2026Article
- Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider.Molecular ecology resources · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Closely related, yet phenotypically different - Genome assemblies of two sister species of widow spiders:GigaByte (Hong Kong, China) · 2026Article
- A Novel Supergene Controls Queen Size and Colony Social Organization in the Ant Myrmica ruginodis.Molecular biology and evolution · 2025Article
- Genomic and transcriptomic analyses of Heteropoda venatoria reveal the expansion of P450 family for starvation resistance in spiders.GigaScience · 2025Article
- Three Novel Spider Genomes Unveil Spidroin Diversification and Hox Cluster Architecture: Ryuthela nishihirai (Liphistiidae), Uloborus plumipes (Uloboridae) and Cheiracanthium punctorium (Cheiracanthiidae).Molecular ecology resources · 2025Article
- Karyotype and genome size analyses for two spiders of the lycosidae family.Frontiers in genetics · 2025Article
- Orthopteran Neo-Sex Chromosomes Reveal Dynamics of Recombination Suppression and Evolution of Supergenes.Molecular ecology · 2024Article
- Supergenes are not necessary to explain the maintenance of complex alternative phenotypes.Proceedings. Biological sciences · 2024Article
- Identification and Evolutionary Analysis of the Widely Distributed CAP Superfamily in Spider Venom.Toxins · 2024Article
- The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies.Nature ecology & evolution · 2024Article
- Lampshade web spider Ectatosticta davidi chromosome-level genome assembly provides evidence for its phylogenetic position.Communications biology · 2023Article
- One to host them all: genomics of the diverse bacterial endosymbionts of the spiderMicrobial genomics · 2023Article
- Chromosome-level genome and the identification of sex chromosomes in Uloborus diversus.GigaScience · 2022Article
- A Novel Widespread MITE Element in the Repeat-Rich Genome of theMicrobiology spectrum · 2022Article
- A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility.Genome research · 2022Article
- Genomic evidence that a sexually selected trait captures genome-wide variation and facilitates the purging of genetic load.Nature ecology & evolution · 2022Article
- Ecology and evolution of chlamydial symbionts of arthropods.ISME communications · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
In many species, individuals can develop into strikingly different morphs, which are determined by a simple Mendelian locus. How selection shapes loci that control complex phenotypic differences remains poorly understood. In the spider Oedothorax gibbosus, males develop either into a 'hunched' morph with conspicuous head structures or as a fast-developing 'flat' morph with a female-like appearance. We show that the hunched-determining allele contains a unique genomic fragment of approximately 3 megabases that is absent in the flat-determining allele. This fragment comprises dozens of genes that duplicated from genes found at the same as well as different chromosomes. All functional duplicates, including a duplicate of the key sexual differentiation regulatory gene doublesex, show male-specific expression, which illustrates their integrated role as a masculinizing supergene. Our findings demonstrate how extensive indel polymorphisms and duplications of regulatory genes may contribute to the evolution of co-adapted gene clusters, sex-limited reproductive morphs and the enigmatic evolution of exaggerated sexual traits in general.
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