ArticleNature methods2022
Fast optical recording of neuronal activity by three-dimensional custom-access serial holography.
Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- A versatile, positive-going voltage indicator that enables accessible two-photon recordings in vivo.bioRxiv : the preprint server for biology · 2026Article
- Voltage imaging as a window into neural computation.Neurophotonics · 2026Article
- Multiphoton Neurophotonics: Recent Advances in Imaging and Manipulating Neuronal Circuits.ACS photonics · 2025Review
- Two-photon all-optical neurophysiology for the dissection of larval zebrafish brain functional and effective connectivity.Communications biology · 2024Article
- Neurophotonics beyond the surface: unmasking the brain's complexity exploiting optical scattering.Neurophotonics · 2024Article
- Demixing fluorescence time traces transmitted by multimode fibers.Nature communications · 2024Article
- Deep Learning Enhanced Label-Free Action Potential Detection Using Plasmonic-Based Electrochemical Impedance Microscopy.Analytical chemistry · 2024Article
- Scanless two-photon voltage imaging.Nature communications · 2024Article
- Acousto-optic holography for pseudo-two-dimensional dynamic light patterning.APL photonics · 2024Article
- Neurophotonics beyond the Surface: Unmasking the Brain's Complexity Exploiting Optical Scattering.ArXiv · 2024Article
- Fast wavefront shaping for two-photon brain imaging with multipatch correction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ten-kilohertz two-photon microscopy imaging of single-cell dendritic activity and hemodynamicsNeurophotonics · 2023Article
- Multi-neuronal recording in unrestrained animals with all acousto-optic random-access line-scanning two-photon microscopy.Frontiers in neuroscience · 2023Article
- Two-photon calcium imaging of neuronal activity.Nature reviews. Methods primers · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Optical recording of neuronal activity in three-dimensional (3D) brain circuits at cellular and millisecond resolution in vivo is essential for probing information flow in the brain. While random-access multiphoton microscopy permits fast optical access to neuronal targets in three dimensions, the method is challenged by motion artifacts when recording from behaving animals. Therefore, we developed three-dimensional custom-access serial holography (3D-CASH). Built on a fast acousto-optic light modulator, 3D-CASH performs serial sampling at 40 kHz from neurons at freely selectable 3D locations. Motion artifacts are eliminated by targeting each neuron with a size-optimized pattern of excitation light covering the cell body and its anticipated displacement field. Spike rates inferred from GCaMP6f recordings in visual cortex of awake mice tracked the phase of a moving bar stimulus with higher spike correlation between intra compared to interlaminar neuron pairs. 3D-CASH offers access to the millisecond correlation structure of in vivo neuronal activity in 3D microcircuits.
Indexed as
Identifiers
34949810What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.