Evidence map›Paper›PMID 34949809›Full record

ArticleNature methods2022

FlyWire: online community for whole-brain connectomics.

Sven Dorkenwald, Claire E McKellar, Thomas Macrina, Nico Kemnitz, Kisuk Lee, Ran Lu, Jingpeng Wu, Sergiy Popovych, Eric Mitchell, Barak Nehoran and 33 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

170 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  17. Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  18. Article
  19. Review
  20. Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026
    Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Sven Dorkenwald *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Claire E McKellar *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Thomas Macrina *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-0622-9338
Nico Kemnitz *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Kisuk Lee *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ran Lu *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Jingpeng Wu *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sergiy PopovychPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Eric MitchellPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-7487-1744
Barak NehoranPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-7371-0829
Zhen JiaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
J Alexander BaePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-4681-6342
Shang MuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Dodam IhPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Manuel CastroPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-2787-0332
Oluwaseun OgedengbePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Akhilesh HalageriPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Kai KuehnerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Zoe AshwoodPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Jonathan ZungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Derrick BrittainAllen Institute for Brain Science, Seattle, WA, USA.
Forrest CollmanAllen Institute for Brain Science, Seattle, WA, USA.
Casey Schneider-MizellAllen Institute for Brain Science, Seattle, WA, USA.
Chris JordanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
William SilversmithPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Christa BakerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
David DeutschPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8587-2435
Lucas Encarnacion-RiveraPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sandeep KumarPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-7181-232X
Austin BurkePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Doug BlandPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Jay GagerPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
James HebditchPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Selden KoolmanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Merlin MoorePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Sarah MorejohnPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ben SilvermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Kyle WilliePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ryan WilliePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Mala MurthyPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. mmurthy@princeton.edu.ORCID http://orcid.org/0000-0003-3063-3389
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. sseung@princeton.edu.ORCID http://orcid.org/0000-0002-8591-6733

Funding

Collaboratory for atlasing cell type anatomy in the female and male mouse brainU01MH114824 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$11.7M
Towards integrated 3D reconstruction of whole human brains at subcellular resolutionU01MH117072 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHUNG, KWANGHUN · 2018 to 2022
$8.8M
Structure and Function of a Cubic Millimeter of Cortex: Crowdsourcing for Proofreading and DiscoveryRF1MH123400 · NIMH · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2020 to 2020
$6.4M
Uncovering the Neural Mechanisms that Flexibly Link Sensory Processing to BehaviorR35NS111580 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2019 to 2026
$5.0M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Howard Hughes Medical InstituteNIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH123400NIMH NIH HHS U01 MH114824NIMH NIH HHS U01 MH117072NINDS NIH HHS R35 NS111580
6 · The paper itself

Abstract

Due to advances in automated image acquisition and analysis, whole-brain connectomes with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated reconstructions will require many person-years of effort, due to the huge volumes of data involved. Here we present FlyWire, an online community for proofreading neural circuits in a Drosophila melanogaster brain and explain how its computational and social structures are organized to scale up to whole-brain connectomics. Browser-based three-dimensional interactive segmentation by collaborative editing of a spatially chunked supervoxel graph makes it possible to distribute proofreading to individuals located virtually anywhere in the world. Information in the edit history is programmatically accessible for a variety of uses such as estimating proofreading accuracy or building incentive systems. An open community accelerates proofreading by recruiting more participants and accelerates scientific discovery by requiring information sharing. We demonstrate how FlyWire enables circuit analysis by reconstructing and analyzing the connectome of mechanosensory neurons.

Indexed as

SoftwareAnimalsBrainComputer GraphicsConnectomeData VisualizationDrosophila melanogasterImaging, Three-DimensionalNeurons

Identifiers

PMID34949809
PMCPMC8903166

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.