ArticleNature methods2022
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4
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Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles.Molecular therapy. Nucleic acids · 2026Article
- Targeted Nanoparticle Delivery CRISPR/Cas9: overcoming biological barriers, enhancing stability, and improving therapeutic precision.International journal of pharmaceutics: X · 2026Review
- Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity.Science advances · 2026Article
- High-titer modular retroviral vectors enabled by an antisense cassette design preventing dsRNA formation during virus production.Molecular therapy. Advances · 2026Article
- CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16European journal of immunology · 2026Article
- Article
- FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes.The Journal of experimental medicine · 2026Article
- Evasion of CARD8 activation during HIV-1 assembly.Science advances · 2025Article
- Aquarius helicase facilitates HIV-1 integration into R-loop enriched genomic regions.Nature microbiology · 2025Article
- Article
- Establishment of a reverse genetics system for studying human immune functions in mice.Science advances · 2025Article
- CPSF6 promotes HIV-1 preintegration complex function.Journal of virology · 2025Article
- Keratin-72 restricts HIV-1 infection in resting CD4Nature communications · 2025Article
- Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2'O-methylation.EMBO reports · 2024Article
- HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration.Nucleic acids research · 2024Article
- TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3ζ.bioRxiv : the preprint server for biology · 2024Article
- Biopotency and surrogate assays to validate the immunomodulatory potency of extracellular vesicles derived from mesenchymal stem/stromal cells for the treatment of experimental autoimmune uveitis.Journal of extracellular vesicles · 2024Article
- Role of immune cell interactions in alcohol-associated liver diseases.Liver research (Beijing, China) · 2024Review
- Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells.Cell reports. Medicine · 2024Article
- Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression.PLoS pathogens · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Manuel Albanese *Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany. Albanese@mvp.uni-muenchen.de.ORCID http://orcid.org/0000-0002-4614-7599
Adrian Ruhle *Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Jennifer MittermaierMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Ernesto Mejías-PérezMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-5208-8177
Madeleine GappMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Andreas LinderGene Center and Department of Biochemistry, LMU München, Munich, Germany.
Niklas A SchmackeGene Center and Department of Biochemistry, LMU München, Munich, Germany.
Katharina HofmannMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
Alexandru A HennrichMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-3233-6145
David N LevyDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.
Andreas HumpeDepartment of Transfusion Medicine, Cell Therapeutics, and Hemostaseology, Department of Anesthesiology, University Hospital Munich, Munich, Germany.
Karl-Klaus ConzelmannMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-8614-3656
Veit HornungGene Center and Department of Biochemistry, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-4150-194X
Oliver T FacklerDepartment of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2982-4209
Oliver T KepplerMax von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany. keppler@mvp.uni-muenchen.de.ORCID http://orcid.org/0000-0002-1384-8946
Funding
Establishing HIV-1 chromatin in resting T cells: Vpr, latency, and H2A.ZR01AI145753 · NIAID · NEW YORK UNIVERSITY · PI LEVY, DAVID N · 2019 to 2023
$2.0MNIAID NIH HHS R01 AI145753
Abstract
CD4
Indexed as
CD4-Positive T-LymphocytesCell MovementCells, CulturedCRISPR-Associated Protein 9CRISPR-Cas SystemsDNAGene EditingGene Knockout TechniquesHIV InfectionsHumansMembrane GlycoproteinsmRNA Cleavage and Polyadenylation FactorsMyxovirus Resistance ProteinsRNA, Guide, CRISPR-Cas SystemsSAM Domain and HD Domain-Containing Protein 1Transgenescleavage factor Im, humanCRISPR-Associated Protein 9DNAMembrane GlycoproteinsmRNA Cleavage and Polyadenylation FactorsMX2 protein, humanMyxovirus Resistance ProteinsP-selectin ligand proteinRNA, Guide, CRISPR-Cas SystemsSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.