Evidence map›Paper›PMID 34949712›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR.

Gatikrushna Singh, Bradley Seufzer, Zhenwei Song, Dora Zucko, Xiao Heng, Kathleen Boris-Lawrie

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  3. Macropinosomes are a site of HIV-1 entry into primary CD4Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  9. Editorial: The role of autophagy in cardiovascular disease.Frontiers in cell and developmental biology · 2025
    Article
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  18. Article
  19. The role of autophagy in the progression of HIV infected cardiomyopathy.Frontiers in cell and developmental biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gatikrushna SinghDepartment of Veterinary and Biomedical Sciences, University of Minnesota-Twin Cities, Saint Paul, MN 55108; kbl@umn.edu gsingh@umn.edu hengx@missouri.edu.ORCID 0000-0002-9870-5556
Bradley SeufzerDepartment of Veterinary and Biomedical Sciences, University of Minnesota-Twin Cities, Saint Paul, MN 55108.
Zhenwei SongDepartment of Biochemistry, University of Missouri, Columbia, MO 65211.
Dora ZuckoDepartment of Veterinary and Biomedical Sciences, University of Minnesota-Twin Cities, Saint Paul, MN 55108.
Xiao HengDepartment of Biochemistry, University of Missouri, Columbia, MO 65211 kbl@umn.edu gsingh@umn.edu hengx@missouri.edu.ORCID 0000-0001-8448-3596
Kathleen Boris-LawrieDepartment of Veterinary and Biomedical Sciences, University of Minnesota-Twin Cities, Saint Paul, MN 55108; kbl@umn.edu gsingh@umn.edu hengx@missouri.edu.ORCID 0000-0001-6366-6270
University of Minnesota · USUniversity of Missouri · US

Funding

Structural basis of the HIV-1 PBS-segment mediated RHA recruitment during assembly to bolster virus infectivityR01AI150460 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI HENG, XIAO · 2019 to 2021
$916k
NIAID NIH HHS R01 AI150460
6 · The paper itself

Abstract

Appended to the 5' end of nascent RNA polymerase II transcripts is 7-methyl guanosine (m

Indexed as

5' Untranslated RegionsBinding SitesDEAD-box RNA HelicasesEukaryotic Initiation Factor-4EGuanosineHIV-1Host Microbial InteractionsHumansLicensureMethylationMethyltransferasesNeoplasm ProteinsRNA CapsRNA, MessengerRNA, ViralTOR Serine-Threonine Kinases5' Untranslated Regions7-methylguanosineDEAD-box RNA HelicasesDHX9 protein, humanEukaryotic Initiation Factor-4EGuanosineMethyltransferasesMTOR protein, humanNeoplasm ProteinsRNA CapsRNA, MessengerRNA, ViralTOR Serine-Threonine Kinasestrimethylguanosine synthaseeIF4E inactivationm7G-cap methylationnuclear RNA helicaseRNA fatevirus–host interaction

Identifiers

PMID34949712
PMCPMC8740576
OpenAlexW4200522849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.