Evidence map›Paper›PMID 34949706›Full record

ReviewThe European respiratory journal2022

ERS/ATS technical standard on interpretive strategies for routine lung function tests.

Sanja Stanojevic, David A Kaminsky, Martin R Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G Cooper, Bruce Culver, Eric Derom, Graham L Hall and 6 more

4 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 926 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
926citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06119087 nacompletednot on this mapstarted 2024, after this paper: background citation

Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study

TypeinterventionalSponsorUniversity of PennsylvaniaRan2024 to 2026Enrolled23ConditionsAmyotrophic Lateral Sclerosis, Chronic Respiratory Failure, Airway Clearance Impairment, Neuromuscular DiseasesArmsMechanical insufflation
NCT06571942 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Effect of the Inhaled Triple Therapies Over the Small Airway in Patients With Chronic Obstructive Pulmonary Disease or Chronic Bronchitis Without Obstruction Secondary to Biomass Exposure: Randomized Controlled Clinical Trial Phase IV

TypeinterventionalSponsorNational Institute of Respiratory Diseases, MexicoRan2023 to 2025Enrolled128ConditionsCOPD Bronchitis, Pollution Related Respiratory DisorderArmsVilanterol / Umeclidinium (25/62.5 mcg), Fluthicasone / Vilanterol / Umeclidinium (100/25/62.5 mcg), Beclomethasone / Formoterol / Glycopyrronyum 100/6/12.5 mcg, Budesonide / Formoterol / Glycopyrronyum 160/4.8/7.2 mcg
NCT07179952 phase2not yet recruitingnot on this mapstarted 2027, after this paper: background citation

A Study to Evaluate Efficacy and Safety of Slow Release DHEA

TypeinterventionalSponsorIndiana UniversityRan2027 to 2028Enrolled30ConditionsAsthmaArmsSlow Release DHEA, Placebo
NCT07372521 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Measuring Small-Airways Disease Improvement After Step-up to Extrafine TRIple or High-dose ICS/LABA in Patients Uncontrolled on Medium Dose ICS/LABA eXploring T2 Inflammation: The MATRIX Real-life Observational Study

Typeobservational_patient_registrySponsorUniversity Hospital, IoanninaRan2026 to 2028Enrolled130ConditionsAsthma
3 · Its place in the literature

Who cites it

926 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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866 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Sanja StanojevicDept of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada sanja.stanojevic@dal.ca.ORCID 0000-0001-7931-8051
David A KaminskyPulmonary Disease and Critical Care Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
Martin R MillerInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0001-9971-5759
Bruce ThompsonPhysiology Service, Dept of Respiratory Medicine, The Alfred Hospital and School of Health Sciences, Swinburne University of Technology, Melbourne, Australia.
Andrea AlivertiDept of Electronics, Information and Bioengineering (DEIB), Politecnico di Milano, Milan, Italy.
Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, University of California, Los Angeles, CA, USA.
Brendan G CooperLung Function and Sleep, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Bruce CulverDept of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.
Eric DeromDept of Respiratory Medicine, Ghent University, Ghent, Belgium.
Graham L HallChildren's Lung Health, Wal-yan Respiratory Research Centre, Telethon Kids Institute and School of Allied Health, Faculty of Health Science, Curtin University, Bentley, Australia.
Teal S HallstrandDept of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.
Joerg D LeuppiUniversity Clinic of Medicine, Cantonal Hospital Basel, Liestal, Switzerland.
Neil MacIntyreDivision of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, Duke University Medical Center, Durham, NC, USA.
Meredith McCormackPulmonary Function Laboratory, Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Margaret RosenfeldSeattle Children's Hospital, Seattle, WA, USA.
Erik R SwensonDept of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAppropriate interpretation of pulmonary function tests (PFTs) involves the classification of observed values as within/outside the normal range based on a reference population of healthy individuals, integrating knowledge of physiological determinants of test results into functional classifications and integrating patterns with other clinical data to estimate prognosis. In 2005, the American Thoracic Society (ATS) and European Respiratory Society (ERS) jointly adopted technical standards for the interpretation of PFTs. We aimed to update the 2005 recommendations and incorporate evidence from recent literature to establish new standards for PFT interpretation.

methodsThis technical standards document was developed by an international joint Task Force, appointed by the ERS/ATS with multidisciplinary expertise in conducting and interpreting PFTs and developing international standards. A comprehensive literature review was conducted and published evidence was reviewed.

resultsRecommendations for the choice of reference equations and limits of normal of the healthy population to identify individuals with unusually low or high results are discussed. Interpretation strategies for bronchodilator responsiveness testing, limits of natural changes over time and severity are also updated. Interpretation of measurements made by spirometry, lung volumes and gas transfer are described as they relate to underlying pathophysiology with updated classification protocols of common impairments.

conclusionsInterpretation of PFTs must be complemented with clinical expertise and consideration of the inherent biological variability of the test and the uncertainty of the test result to ensure appropriate interpretation of an individual's lung function measurements.

Indexed as

Bronchodilator AgentsRespiratory SystemHumansLung Volume MeasurementsRespiratory Function TestsSpirometryUnited StatesBronchodilator Agents

Identifiers

PMID34949706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.