Evidence map›Paper›PMID 34949685›Full record

ArticleeNeuro

Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model.

Enhui Pan, Ram S Puranam, James O McNamara

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Enhui PanDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710.
Ram S PuranamDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0003-4383-3849
James O McNamaraDepartment of Neurology, Duke University School of Medicine, Durham, NC 27710 jmc@neuro.duke.edu.
Duke University · US

Funding

Neurotrophins and EpileptogenesisR01NS056217 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2006 to 2023
$6.7M
Cellular and Circuit Mechanisms of Temporal Lobe EpilepsyR01NS097717 · NINDS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 2017 to 2021
$2.2M
NINDS NIH HHS R01 NS056217NINDS NIH HHS R01 NS097717
6 · The paper itself

Abstract

Insight into the cellular and circuit mechanisms underlying development of temporal lobe epilepsy (TLE) will provide a foundation for improved therapies. We studied a model in which an episode of prolonged seizures is followed by recovery lasting two weeks before emergence of spontaneous recurrent seizures. We focused on the interval between the prolonged seizures and the late onset recurrent seizures. We investigated the hippocampal mossy fiber CA3 pyramidal cell microcircuit in models spanning

Indexed as

EpilepsyEpilepsy, Temporal LobeAnimalsLong-Term PotentiationMiceMossy Fibers, HippocampalPyramidal CellsCA3 pyramidal cellsfeedforward inhibitionhomeostaticmossy fiberstatus epilepticus

Identifiers

PMID34949685
PMCPMC8805193
OpenAlexW4200018872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.