Evidence map›Paper›PMID 34949667›Full record

ArticleGenome research2022

Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders.

Ligia A Papale, Andy Madrid, Qi Zhang, Kailei Chen, Lara Sak, Sündüz Keleş, Reid S Alisch

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ligia A Papale *Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53719, USA.
Andy Madrid *Department of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53719, USA.
Qi Zhang *Department Mathematics and Statistics, University of New Hampshire, Durham, New Hampshire 03824, USA.ORCID 0000-0001-6197-0973
Kailei ChenDepartment of Statistics, Biostatistics, and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53719, USA.
Lara SakDepartment of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53719, USA.
Sündüz KeleşDepartment of Statistics, Biostatistics, and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53719, USA.ORCID 0000-0001-9048-0922
Reid S AlischDepartment of Neurological Surgery, University of Wisconsin, Madison, Wisconsin 53719, USA.ORCID 0000-0003-0637-4137
University of Wisconsin System · USUniversity of Wisconsin–Madison · USUniversity of New Hampshire · US

Funding

TrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3M
Statistical Methods for the Analysis of ChlP-chip DataR01HG003747 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI KELES, SUNDUZ · 2007 to 2024
$4.8M
Statistical Methods For Annotating Repetitive Genomic Regions Through ENCODE-deriU01HG007019 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI BRESNICK, EMERY H, DEWEY, COLIN NOEL · 2012 to 2015
$1.5M
Functionally relevant mapping of human GWAS SNPs on model organismsR21HG011371 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI KELES, SUNDUZ · 2020 to 2020
$400k
Defining the Molecular Origins of Developmental Brain DisordersF31MH113351 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MADRID, ANDY · 2017 to 2019
$98k
NHGRI NIH HHS R01 HG003747NHGRI NIH HHS R21 HG011371NHGRI NIH HHS U01 HG007019NIAID NIH HHS U54 AI117924NIMH NIH HHS F31 MH113351
6 · The paper itself

Abstract

Mouse knockouts of

Indexed as

Gene-Environment InteractionNeurodevelopmental Disorders5-MethylcytosineAnimalsDNA MethylationEpigenesis, GeneticFemaleMembrane ProteinsMiceNerve Tissue ProteinsPregnancy5-hydroxymethylcytosine5-MethylcytosineCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue Proteins

Identifiers

PMID34949667
PMCPMC8805724
OpenAlexW4221096666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.