Evidence map›Paper›PMID 34949631›Full record

ArticleBMJ open2021

Evaluation of a two-way SMS messaging strategy to reduce neonatal mortality: rationale, design and methods of the Mobile WACh NEO randomised controlled trial in Kenya.

Keshet Ronen, Esther M Choo, Brenda Wandika, Jenna I Udren, Lusi Osborn, Peninah Kithao, Anna B Hedstrom, Millicent Masinde, Manasi Kumar, Dalton C Wamalwa and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04598165 (Mobile WACh NEO Randomized Clinical Trial), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04598165 nacompletednot on this map

Mobile WACh NEO Randomized Clinical Trial: Mobile Phone 2-Way Short Message Service (SMS) Versus Control to Reduce Neonatal Mortality in Kenya

TypeinterventionalSponsorWomen and Infants Hospital of Rhode IslandRan2020 to 2023Enrolled5,020ConditionsNeonatal Death, Perinatal Death, DepressionArmsInteractive two-way SMS dialogue
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Keshet RonenDepartment of Global Health, University of Washington, Seattle, Washington, USA keshet@uw.edu.ORCID 0000-0001-5625-4884
Esther M ChooDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Brenda WandikaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Jenna I UdrenDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Lusi OsbornDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Peninah KithaoDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Anna B HedstromDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Millicent MasindeDepartment of Obstetrics and Gynecology, Kenyatta National Hospital, Nairobi, Kenya.
Manasi KumarDepartment of Psychiatry, University of Nairobi, Nairobi, Kenya.
Dalton C WamalwaDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Barbra A RichardsonDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
John KinuthiaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Jennifer A UngerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
University of Washington · USKenyatta National Hospital · KEUniversity of Nairobi · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Mobile WACh NEO: Mobile Solutions for Neonatal Health and Maternal SupportR01HD098105 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI UNGER, JENNIFER · 2019 to 2023
$2.8M
Mapping impact and developing mitigation strategies for climate change-mental health nexus in the context of vulnerable adolescent populations in KenyaK43TW010716 · FIC · UNIVERSITY OF NAIROBI · PI KUMAR, MANASI · 2018 to 2022
$648k
Leveraging interactive SMS messaging to monitor and support maternal mental health in KenyaK18MH122978 · NIMH · UNIVERSITY OF WASHINGTON · PI RONEN, KESHET · 2020 to 2021
$256k
FIC NIH HHS K43 TW010716NIAID NIH HHS P30 AI027757NICHD NIH HHS R01 HD098105NIMH NIH HHS K18 MH122978
6 · The paper itself

Abstract

introductionGlobally, approximately half of the estimated 6.3 million under-5 deaths occur in the neonatal period (within the first 28 days of life). Kenya ranks among countries with the highest number of neonatal deaths, at 20 per 1000 live births. Improved identification and management of neonates with potentially life-threatening illness is critical to meet the WHO's target of ≤12 neonatal deaths per 1000 live births by 2035. We developed an interactive (two-way) short messaging service (SMS) communication intervention, Mobile Solutions for Neonatal Health (Mobile women's and children's health (WACh) NEO), focused on the perinatal period. Mobile WACh NEO sends automated tailored SMS messages to mothers during pregnancy and up to 6 weeks post partum. Messages employ the Information-Motivation-Behaviour Skills framework to promote (1) maternal implementation of essential newborn care (ENC, including early, exclusive breast feeding, cord care and thermal care), (2) maternal identification of neonatal danger signs and care-seeking, and (3) maternal social support and self-efficacy. Participants can also send SMS to the study nurse, enabling on-demand remote support. METHODS AND ANALYSIS: We describe a two-arm unblinded randomised controlled trial of the Mobile WACh NEO intervention. We will enrol 5000 pregnant women in the third trimester of pregnancy at 4 facilities in Kenya and randomise them 1:1 to receive interactive SMS or no SMS (control), and conduct follow-up visits at 2 and 6 weeks post partum. Neonatal mortality will be compared between arms as the primary outcome. Secondary outcomes include care-seeking, practice of ENC and psychosocial health. Exploratory analysis will investigate associations between maternal mental health, practice of ENC, care-seeking and SMS engagement. ETHICS AND DISSEMINATION: This study received ethical approval from the University of Washington (STUDY00006395), Women and Infants Hospital (1755292-1) and Kenyatta National Hospital/University of Nairobi (P310/04/2019). All participants will provide written informed consent. Findings will be published in peer-reviewed journals and international conferences. TRIAL REGISTRATION NUMBER: NCT04598165.

Indexed as

Child HealthText MessagingChildFemaleHumansInfantInfant MortalityInfant, NewbornKenyaPregnancyRandomized Controlled Trials as TopicWomen's Healthdepression & mood disordersneonatologytelemedicine

Identifiers

PMID34949631
PMCPMC9066367
OpenAlexW4200303047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.