Evidence map›Paper›PMID 34949593›Full record

ArticleAJNR. American journal of neuroradiology2022

Feasibility and Added Value of Fetal DTI Tractography in the Evaluation of an Isolated Short Corpus Callosum: Preliminary Results.

A-E Millischer, D Grevent, P Sonigo, N Bahi-Buisson, I Desguerre, H Mahallati, J-P Bault, T Quibel, S Couderc, M-L Moutard and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Prenatal evaluation, diagnosis and management of fetal corpus callosal abnormalities: international Delphi consensus.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  2. Article
  3. Article
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  5. White matter tract crossing and bottleneck regions in the fetal brain.bioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 5 countries.

A-E MillischerFrom the Department of Paediatric Radiology (A.-E.M., D.G., P.S., V.D., N.B.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Paris France aemillischer@gmail.com.ORCID 0000-0002-3692-0998
D GreventFrom the Department of Paediatric Radiology (A.-E.M., D.G., P.S., V.D., N.B.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Paris France.ORCID 0000-0001-6557-2331
P SonigoFrom the Department of Paediatric Radiology (A.-E.M., D.G., P.S., V.D., N.B.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Paris France.
N Bahi-BuissonInstitut Imagine (A.-E.M., D.G., P.S., N.B.-B., I.D., V.D., N.B.), Institut National de la Santé et de la Recherche Médicale U1163, Université de Paris, Paris, France.
I DesguerreInstitut Imagine (A.-E.M., D.G., P.S., N.B.-B., I.D., V.D., N.B.), Institut National de la Santé et de la Recherche Médicale U1163, Université de Paris, Paris, France.ORCID 0000-0002-4074-5862
H MahallatiLUMIERE Platform (A.-E.M., D.G., P.S., H.M., N.B., L.-J.S.), Paris, France.ORCID 0000-0003-3321-6054
J-P BaultDepartments of Gynecology and Obstetrics (J.-P.B., T.Q.).
T QuibelDepartments of Gynecology and Obstetrics (J.-P.B., T.Q.).
S CoudercPediatrics (S.C.), CHI, Poissy Saint-Germain, France.ORCID 0000-0002-8025-4785
M-L MoutardDepartment of Pediatric Neurology (M.-L.M.), Trousseau Hospital, CHU, Trousseau, Paris.
E JulienDepartment of Gynecology-Obstetrics (E.J.), Hospital Le Mans, Le Mans, France.
V DangouloffFrom the Department of Paediatric Radiology (A.-E.M., D.G., P.S., V.D., N.B.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Paris France.
B BessieresAnatomical Pathology (B.B.).
V MalanGenetics (V.M., T.A.), Necker Enfants Malades University Hospital, Université de Paris, Paris, France.
T AttieGenetics (V.M., T.A.), Necker Enfants Malades University Hospital, Université de Paris, Paris, France.
L-J SalomonDepartment of Gynecology-Obstetrics (L.-J.S.), Université de Paris, Paris, France.
N BoddaertFrom the Department of Paediatric Radiology (A.-E.M., D.G., P.S., V.D., N.B.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants Malades, Université de Paris, Paris France.ORCID 0000-0003-0991-7774
Hôpital Necker-Enfants Malades · FRB2 (Slovenia) · SIHesco (United States) · USBT Research · GBCentre Hospitalier du Mans · FRCentre Hospitalier Intercommunal de Poissy · FRSorbonne Université · FRUniversité Paris Cité · FRUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposePrognosis of isolated short corpus callosum is challenging. Our aim was to assess whether fetal DTI tractography can distinguish callosal dysplasia from variants of normal callosal development in fetuses with an isolated short corpus callosum. MATERIALS AND

methodsThis was a retrospective study of 37 cases referred for fetal DTI at 30.4 weeks (range, 25-34 weeks) because of an isolated short corpus callosum  less than the 5th percentile by sonography at 26 weeks (range, 22-31 weeks). Tractography quality, the presence of Probst bundles, dysmorphic frontal horns, callosal length (internal cranial occipitofrontal dimension/length of the corpus callosum ratio), and callosal thickness were assessed. Cytogenetic data and neurodevelopmental follow-up were systematically reviewed.

resultsThirty-three of 37 fetal DTIs distinguished the 2 groups: those with Probst bundles (Probst bundles+) in 13/33 cases (40%) and without Probst bundles (Probst bundles-) in 20/33 cases (60%). Internal cranial occipitofrontal dimension/length of the corpus callosum was significantly higher in Probst bundles+ than in Probst bundles-, with a threshold value determined at 3.75 for a sensitivity of 92% (95% CI, 77%-100%) and specificity of 85% (95% CI, 63%-100%). Callosal lipomas (4/4) were all in the Probst bundles- group. More genetic anomalies were found in the Probst bundles+ than in Probst bundles- group (23% versus 10%,

conclusionsFetal DTI, combined with anatomic, cytogenetic, and clinical characteristics could suggest the possibility of classifying an isolated short corpus callosum as callosal dysplasia and a variant of normal callosal development.

Indexed as

Agenesis of Corpus CallosumCorpus CallosumFeasibility StudiesFetusHumansRetrospective Studies

Identifiers

PMID34949593
PMCPMC8757544
OpenAlexW4200457823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.