ReviewTrends in immunology2022
The evolution of powerful yet perilous immune systems.
Review in Trends in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines.Cell metabolism · 2026Article
- Host-associated beneficial gut microbiota boosts induced immunity and limits immune deployment costs in bumblebees.The Journal of animal ecology · 2026Article
- Molecular mimicry revisited: novel perspectives on autoimmune disease initiation and progression.Frontiers in immunology · 2026Review
- T-helper cell phenotypes are repeatable, positively correlated, and associated with helminth infection in wild Soay sheep.Discovery immunology · 2025Article
- Microbial surveillance versus cytokine responsiveness in native and non-native house sparrows.Biology letters · 2025Article
- Roles of chemical species transport and transformation in the biophysics of human pathophysiology.npj biological physics and mechanics · 2025Review
- Oncolytic virus therapy in the elderly: immune frailty, challenges, and perspectives.Frontiers in immunology · 2025Review
- Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.International journal of molecular sciences · 2024Article
- Protozoan-Derived Cytokine-Transgenic Macrophages Reverse Hepatic Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus.Frontiers in immunology · 2024Article
- Genetic predisposition to milder forms of COVID-19 may provide some resilience to head and neck cancers.Frontiers in oncology · 2024Article
- Assessing immune phenotypes using simple proxy measures: promise and limitations.Discovery immunology · 2024Article
- Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development.Development (Cambridge, England) · 2023Article
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks.bioRxiv : the preprint server for biology · 2023Article
- The adaptive microbiome hypothesis and immune interactions in amphibian mucus.Developmental and comparative immunology · 2023Review
- Epidemiological impacts of post-infection mortality.Proceedings. Biological sciences · 2023Article
- Endothelial Cell SMAD6 Balances ACVRL1/Alk1 Function to Regulate Adherens Junctions and Hepatic Vascular Development.bioRxiv : the preprint server for biology · 2023Article
- Revising immune cell coordination: Origins and importance of single-cell variation.European journal of immunology · 2022Review
- Evolutionary gain and loss of a pathological immune response to parasitism.Science (New York, N.Y.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian immune system packs serious punch against infection but can also cause harm: for example, coronavirus disease 2019 (COVID-19) made headline news of the simultaneous power and peril of human immune responses. In principle, natural selection leads to exquisite adaptation and therefore cytokine responsiveness that optimally balances the benefits of defense against its costs (e.g., immunopathology suffered and resources expended). Here, we illustrate how evolutionary biology can predict such optima and also help to explain when/why individuals exhibit apparently maladaptive immunopathological responses. Ultimately, we argue that the evolutionary legacies of multicellularity and life-history strategy, in addition to our coevolution with symbionts and our demographic history, together explain human susceptibility to overzealous, pathology-inducing cytokine responses. Evolutionary insight thereby complements molecular/cellular mechanistic insights into immunopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.