Evidence map›Paper›PMID 34949516›Full record

ReviewTrends in microbiology2022

Serotype 1 pneumococcus: epidemiology, genomics, and disease mechanisms.

Chrispin Chaguza, Marie Yang, Laura C Jacques, Stephen D Bentley, Aras Kadioglu

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Molecular Epidemiology ofInternational journal of molecular sciences · 2025
    Pooled it
  2. Pooled it
  3. Article
  4. Molecular Characterization ofMicroorganisms · 2026
    Article
  5. Transcriptomic analysis ofMicrobial genomics · 2025
    Article
  6. Review
  7. Article
  8. Genomic surveillance of invasiveMicrobial genomics · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chrispin ChaguzaParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Darwin College, University of Cambridge, Silver Street, Cambridge, UK; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK; NIHR Mucosal Pathogens Research Unit, Division of Infection and Immunity, University College London, London, UK. Electronic address: Chrispin.Chaguza@sanger.ac.uk.
Marie YangDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK.
Laura C JacquesDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK. Electronic address: ljacques@liverpool.ac.uk.
Stephen D BentleyParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, UK.
Aras KadiogluDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, The Ronald Ross Building, West Derby St, Liverpool, UK.
University of Liverpool · GBIda Darwin hospital · GBWellcome Sanger Institute · GB

Funding

Medical Research Council MR/P011284/1Medical Research Council MR/R002592/1Medical Research Council MR/R003076/1Wellcome TrustWellcome Trust 206194
6 · The paper itself

Abstract

Streptococcus pneumoniae (the 'pneumococcus') is a significant cause of morbidity and mortality worldwide, causing life-threatening diseases such as pneumonia, bacteraemia, and meningitis, with an annual death burden of over one million. Discovered over a century ago, pneumococcal serotype 1 (S1) is a significant cause of these life-threatening diseases. Our understanding of the epidemiology and biology of pneumococcal S1 has significantly improved over the past two decades, informing the development of preventative and surveillance strategies. However, many questions remain unanswered. Here, we review the current state of knowledge of pneumococcal S1, with a special emphasis on clinical epidemiology, genomics, and disease mechanisms.

Indexed as

Pneumococcal InfectionsStreptococcus pneumoniaeGenomicsHumansSerogroupgenomicsinvasivenessoutbreakspneumococcusserotype 1virulence

Identifiers

PMID34949516
PMCPMC7613904
OpenAlexW4200470613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.